Daniel Liebler
Faculty Member
Last active: 2/15/2016

Safety assessment of alkyl PEG ethers as used in cosmetics.

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA
Int J Toxicol. 2012 31 (5 Suppl): 169S-244S

PMID: 23064774 · DOI:10.1177/1091581812444141

The CIR Expert Panel assessed the safety of Alkyl PEG Ethers as used in cosmetics. These ingredients primarily function in cosmetics as surfactants, and some have additional functions as skin-conditioning agents, fragrance ingredients, and emulsion stabilizers. The Panel reviewed available relevant animal and clinical data, as well as information from previous CIR reports; when data were not available for individual ingredients, the Panel extrapolated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol repeat units.

MeSH Terms (14)

Administration, Cutaneous Alkylation Animals Consumer Product Safety Cosmetics Dermatologic Agents Ethers Humans Lethal Dose 50 No-Observed-Adverse-Effect Level Polyethylene Glycols Skin Care Surface-Active Agents Toxicity Tests

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