Daniel Liebler
Faculty Member
Last active: 2/15/2016

Safety assessment of 1,2-glycols as used in cosmetics.

Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA
Int J Toxicol. 2012 31 (5 Suppl): 147S-68S

PMID: 23064773 · DOI:10.1177/1091581812460409

Caprylyl glycol and related 1,2-glycols are used mostly as skin and hair conditioning agents and viscosity agents in cosmetic products, and caprylyl glycol and pentylene glycol also function as cosmetic preservatives. The Cosmetic Ingredient Review (CIR) Expert Panel noted that, while these ingredients are dermally absorbed, modeling data predicted decreased skin penetration of longer chain 1,2-glycols. Because the negative oral toxicity data on shorter chain 1,2-glycols and genotoxicity data support the safety of the 1,2-glycols reviewed in this safety assessment, the Panel concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.

MeSH Terms (14)

Administration, Cutaneous Animals Consumer Product Safety Cosmetics Dermatologic Agents Glycols Humans Lethal Dose 50 No-Observed-Adverse-Effect Level Octanols Pentanes Skin Care Toxicity Tests Viscosity

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