Daniel Liebler
Faculty Member
Last active: 2/15/2016

Safety assessment of xylene sulfonic acid, toluene sulfonic acid, and alkyl aryl sulfonate hydrotropes as used in cosmetics.

Bergfeld WF, Belsito DV, Klaassen CD, Hill R, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA
Int J Toxicol. 2011 30 (6 Suppl): 270S-83S

PMID: 22247238 · DOI:10.1177/1091581811429085

Xylene sulfonic acid, toluene sulfonic acid, and alkyl aryl sulfonate hydrotropes used in cosmetics as surfactants, hydrotropes, were reviewed in this safety assessment. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group. The Cosmetic Ingredient Review Expert Panel reviewed relevant animal and human data related to these ingredients. The panel concluded that xylene sulfonic acid and alkyl aryl sulfonate hydrotropes are safe as cosmetic ingredients in the present practices of use and concentrations as described in this safety assessment, when formulated to be nonirritating.

MeSH Terms (6)

Animals Consumer Product Safety Cosmetics Humans Sulfonic Acids Surface-Active Agents

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