Daniel Liebler
Faculty Member
Last active: 2/15/2016

Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics.

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA
Int J Toxicol. 2010 29 (6 Suppl): 288S-305

PMID: 21164075 · DOI:10.1177/1091581810386124

Sodium dodecylbenzenesulfonate is one of a group of salts of alkylbenzene sulfonates used in cosmetics as surfactant-cleansing agents. Sodium dodecylbenzenesulfonate is soluble in water and partially soluble in alcohol, with dermal absorption dependent on pH. Dodecylbenzenesulfonate salts are not toxic in single-dose oral and dermal animal tests, and no systemic toxicities were observed in repeat-dose dermal animal studies. In dermal animal studies, no evidence of reproductive or developmental toxicity was reported. At 15% concentrations, sodium dodecylbenzenesulfonate was severely irritating to rabbit skin. The Cosmetic Ingredient Review Expert Panel concluded that the irritant properties of these ingredients are similar to those of other detergents, with severity dependent on concentration and pH. Products containing these ingredients should be formulated to ensure that the irritancy potential is minimized.

MeSH Terms (16)

Alkanesulfonic Acids Animals Benzenesulfonates Chemical Phenomena Consumer Product Safety Cosmetics Detergents Dose-Response Relationship, Drug Humans Irritants Mutagenicity Tests Rabbits Skin Surface-Active Agents Toxicity Tests, Acute Toxicity Tests, Chronic

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