Robert Beauchamp
Principal Investigator
Last active: 10/31/2018

Systemic alterations in ornithine decarboxylase activity caused by colon cancer in mice.

Saydjari R, Beauchamp RD, Townsend CM, Thompson JC
Cancer Lett. 1991 58 (1-2): 155-8

PMID: 2049780 · DOI:10.1016/0304-3835(91)90039-k

Tumors are known to cause profound changes in host biology, but the mechanisms responsible for these changes remain unclear. Ornithine decarboxylase (ODC) is a rate-limiting enzyme that catalyzes the biosynthesis of polyamines. The purpose of this study was to examine the effects of MC-26 tumor burden on ODC activity in the gastrointestinal tract, kidney and liver of mice. Forty-four Balb/c mice were randomly divided into 2 groups and the test group was pair-fed (to control). Group 1 was the tumor-free control. Group 2 was inoculated subcutaneously with 5 x 10(5) MC-26 cells. The ODC activity in the kidney and liver of tumor-bearing mice was significantly lower compared to tumor-free controls at sacrifice. ODC activity in the colon increased almost 4-fold. These results suggest that the presence of MC-26 tumor causes systemic effects that alter ODC activity. The tumor may elaborate a substance that suppresses ODC activity in some normal tissues while stimulating ODC activity in the tissue from which the tumor was derived.

MeSH Terms (11)

Animals Colon Colonic Neoplasms Digestive System Kidney Liver Male Mice Mice, Inbred BALB C Neoplasm Transplantation Ornithine Decarboxylase

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