Robert Beauchamp
Principal Investigator
Last active: 10/31/2018

Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells.

Ishizuka J, Beauchamp RD, Evers BM, Townsend CM, Thompson JC
Biochem Biophys Res Commun. 1992 185 (2): 577-81

PMID: 1351720 · DOI:10.1016/0006-291x(92)91663-b

Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic nude mice. In the present study, however, SMS 201-995 did not inhibit in vitro growth of BON cells, but rather SMS 201-995 stimulated growth in a dose-dependent fashion. The growth-stimulatory effect was likely mediated through the reduction of cyclic AMP production. Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.

MeSH Terms (10)

Carcinoid Tumor Cell Division Cyclic AMP Growth Substances Humans In Vitro Techniques Octreotide Phosphatidylinositols Somatostatin Tumor Cells, Cultured

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