The targeted podocyte.

Fogo AB
J Clin Invest. 2011 121 (6): 2142-5

PMID: 21606599 · PMCID: PMC3104780 · DOI:10.1172/JCI57935

The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental settings. In this issue of the JCI, two interesting studies of podocyte-specific manipulation of the mTOR system shed light on the complexity of this pathway in the podocyte.

MeSH Terms (22)

Adaptor Proteins, Signal Transducing Adult Animals Carrier Proteins Child Diabetic Nephropathies Disease Models, Animal Genetic Predisposition to Disease Humans Kidney Glomerulus Mechanistic Target of Rapamycin Complex 1 Mice Mice, Inbred C57BL Multiprotein Complexes Podocytes Proteins Rapamycin-Insensitive Companion of mTOR Protein Regulatory-Associated Protein of mTOR Sirolimus TOR Serine-Threonine Kinases Trans-Activators Transcription Factors

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