Dan Roden
Faculty Member
Last active: 3/24/2020

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting.

Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G
Nat Commun. 2016 7: 12795

PMID: 27731317 · PMCID: PMC5064022 · DOI:10.1038/ncomms12795

MeSH Terms (16)

Adamantane Allosteric Regulation Animals Binding Sites Cross-Linking Reagents Humans Ion Channel Gating KCNQ1 Potassium Channel Models, Molecular Mutagenesis Mutation Oocytes Potassium Channel Blockers Potassium Channels, Voltage-Gated Tandem Mass Spectrometry Xenopus laevis

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