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Dan Roden
Faculty Member
Last active: 3/24/2020

Building evidence and measuring clinical outcomes for genomic medicine.

Peterson JF, Roden DM, Orlando LA, Ramirez AH, Mensah GA, Williams MS
Lancet. 2019 394 (10198): 604-610

PMID: 31395443 · PMCID: PMC6730663 · DOI:10.1016/S0140-6736(19)31278-4

Human genomic sequencing has potential diagnostic, prognostic, and therapeutic value across a wide breadth of clinical disciplines. One barrier to widespread adoption is the paucity of evidence for improved outcomes in patients who do not already have an indication for more focused testing. In this Series paper, we review clinical outcome studies in genomic medicine and discuss the important features and key challenges to building evidence for next generation sequencing in the context of routine patient care.

Copyright © 2019 Elsevier Ltd. All rights reserved.

MeSH Terms (9)

Diagnostic Tests, Routine Genome, Human Genomics Genomics High-Throughput Nucleotide Sequencing Humans Patient Outcome Assessment Precision Medicine Standard of Care

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