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Dan Roden
Faculty Member
Last active: 3/24/2020

Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs.

Roden DM
Card Electrophysiol Clin. 2014 6 (4): 695-704

PMID: 25395995 · PMCID: PMC4226533 · DOI:10.1016/j.ccep.2014.07.003

Although cardiac sodium channel blocking drugs can exert antiarrhythmic actions, they can also provoke life-threatening arrhythmias through a variety of mechanisms. This review addresses the way in which drugs interact with the channel, and how these effects translate to clinical beneficial or detrimental effects. A further understanding of the details of channel function and of drug-channel interactions may lead to the development of safer and more effective antiarrhythmic therapies.

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