The Plk1 Piece of the Nuclear Envelope Disassembly Puzzle.

Dawson TR, Wente SR
Dev Cell. 2017 43 (2): 115-117

PMID: 29065301 · DOI:10.1016/j.devcel.2017.10.010

Reporting in this issue of Developmental Cell, Linder et al. (2017) and Martino et al. (2017) reveal in highly complementary studies that Plk1 is recruited to the nuclear pore complex upon mitotic entry, where it acts with Cdk1 to hyperphosphorylate nucleoporin interfaces to promote NPC disassembly and nuclear envelope breakdown.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (5)

Mitosis Nuclear Envelope Nuclear Pore Nuclear Pore Complex Proteins Phosphorylation

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