Nuclear transport: never-ending cycles of signals and receptors.

Barry DM, Wente SR
Essays Biochem. 2000 36: 89-103

PMID: 12471905

Proteins transported into and out of the nucleus require amino acid motifs called NLSs and NESs, respectively. The amino acid sequences of these signals vary considerably. A superfamily of transport receptors has been identified and each member contains three transport-related domains. Transport receptors bind to the signal sequences, either directly or through adapter proteins, to promote nucleocytoplasmic transport. The diversity of signals, receptors and adapter proteins suggests that there are many pathways for nuclear entry or exit. The direction of transport (into or out of the nucleus) is regulated in part by the small GTPase Ran as well as by intrinsic substrate motifs.

MeSH Terms (9)

Active Transport, Cell Nucleus Animals Cell Nucleus Cytoplasm GTP Phosphohydrolases Guanosine Triphosphate Humans Receptors, Cytoplasmic and Nuclear Signal Transduction

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