The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm.

Ryan KJ, Wente SR
Curr Opin Cell Biol. 2000 12 (3): 361-71

PMID: 10801463

Compositional analysis of nuclear pore complexes (NPCs) is nearing completion, and efforts are now focused on understanding how these protein machines work. Recent analysis of soluble transport factor interactions with NPC proteins reveals distinct and overlapping pathways for movement between the nucleus and cytoplasm. New fluorescence- and microscopy-based strategies have been used to monitor the pathway of NPC assembly and to reveal the dynamics of the NPC during transport.

MeSH Terms (11)

Animals Biological Transport, Active Cell Nucleus Cytoplasm Humans Mitosis Nuclear Envelope Nuclear Proteins Protein Conformation RNA, Messenger Saccharomyces cerevisiae

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