Regulation of chromatin remodeling by inositol polyphosphates.

Steger DJ, Haswell ES, Miller AL, Wente SR, O'Shea EK
Science. 2003 299 (5603): 114-6

PMID: 12434012 · PMCID: PMC1458531 · DOI:10.1126/science.1078062

Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine triphosphate-dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.

MeSH Terms (18)

Adenosine Triphosphatases Chromatin DNA-Binding Proteins Fungal Proteins Gene Expression Regulation, Fungal Inositol Phosphates Mutation Nuclear Proteins Phosphate Transport Proteins Phosphotransferases (Alcohol Group Acceptor) Point Mutation Promoter Regions, Genetic Protein Binding Proton-Phosphate Symporters Saccharomyces cerevisiae Proteins Saccharomycetales Transcription, Genetic Transcription Factors

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