Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport.

Terry LJ, Shows EB, Wente SR
Science. 2007 318 (5855): 1412-6

PMID: 18048681 · DOI:10.1126/science.1142204

Transport of macromolecules between the nucleus and cytoplasm is a critical cellular process for eukaryotes, and the machinery that mediates nucleocytoplasmic exchange is subject to multiple levels of control. Regulation is achieved by modulating the expression or function of single cargoes, transport receptors, or the transport channel. Each of these mechanisms has increasingly broad impacts on transport patterns and capacity, and this hierarchy of control directly affects gene expression, signal transduction, development, and disease.

MeSH Terms (10)

Active Transport, Cell Nucleus Animals Humans Karyopherins Nuclear Envelope Nuclear Export Signals Nuclear Localization Signals Nuclear Pore Nuclear Pore Complex Proteins RNA

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