A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.

York JD, Odom AR, Murphy R, Ives EB, Wente SR
Science. 1999 285 (5424): 96-100

PMID: 10390371 · DOI:10.1126/science.285.5424.96

In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4, 5-bisphosphate to inositol hexakisphosphate (IP6). The common downstream effects of mutations in each component were deficiencies in IP6 synthesis and messenger RNA export, indicating a role for IP6 in GLE1 function and messenger RNA export.

MeSH Terms (16)

Biological Transport Carrier Proteins Genes, Fungal Genetic Complementation Test Inositol Phosphates Mutation Nuclear Envelope Nuclear Pore Complex Proteins Phosphotransferases (Alcohol Group Acceptor) Phytic Acid RNA, Fungal RNA, Messenger Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction Type C Phospholipases

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