Do changes in the c-MYC coding sequence contribute to tumorigenesis?

Chakraborty AA, Tansey WP
Mol Cell Oncol. 2015 2 (2): e965631

PMID: 27308414 · PMCID: PMC4904990 · DOI:10.4161/23723548.2014.965631

The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar protumorigenic effects suggests that these mutations contribute directly to malignancy.

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