Ubiquitin and proteasomes in transcription.

Geng F, Wenzel S, Tansey WP
Annu Rev Biochem. 2012 81: 177-201

PMID: 22404630 · PMCID: PMC3637986 · DOI:10.1146/annurev-biochem-052110-120012

Regulation of gene transcription is vitally important for the maintenance of normal cellular homeostasis. Failure to correctly regulate gene expression, or to deal with problems that arise during the transcription process, can lead to cellular catastrophe and disease. One of the ways cells cope with the challenges of transcription is by making extensive use of the proteolytic and nonproteolytic activities of the ubiquitin-proteasome system (UPS). Here, we review recent evidence showing deep mechanistic connections between the transcription and ubiquitin-proteasome systems. Our goal is to leave the reader with a sense that just about every step in transcription-from transcription initiation through to export of mRNA from the nucleus-is influenced by the UPS and that all major arms of the system--from the first step in ubiquitin (Ub) conjugation through to the proteasome-are recruited into transcriptional processes to provide regulation, directionality, and deconstructive power.

MeSH Terms (8)

Animals DNA-Directed RNA Polymerases Humans Proteasome Endopeptidase Complex Proteolysis Transcription, Genetic Transcription Factors Ubiquitination

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