Mark de Caestecker
Associate Professor of Medicine
Last active: 10/23/2018

Ischemia-reperfusion injury of the mouse kidney.

Oxburgh L, de Caestecker MP
Methods Mol Biol. 2012 886: 363-79

PMID: 22639277 · DOI:10.1007/978-1-61779-851-1_32

Studies of the complex responses of the kidney to acute injury have yielded important insights into mechanisms of tissue injury and repair. A variety of injury models have contributed to this impressive body of knowledge, but the ischemia-reperfusion (IR) model has perhaps been the most widely used. This chapter contains a detailed method description for IR injury in the mouse together with notes on blood sampling and tissue harvesting. The aim of the chapter is to provide the novice with a step-by-step guide to establishing this procedure in their research program.

MeSH Terms (13)

Anesthetics, General Animals Disease Models, Animal Female Hypnotics and Sedatives Isoflurane Ketamine Kidney Male Mice Nephrons Reperfusion Injury Xylazine

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