Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.

Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, Coffey RJ, Goldenring JR
J Clin Invest. 2010 120 (3): 840-9

PMID: 20197623 · PMCID: PMC2827957 · DOI:10.1172/JCI40728

MeSH Terms (18)

Adenocarcinoma Animals Cell Transformation, Neoplastic Colorectal Neoplasms Epithelial Cells Female Gene Expression Regulation, Neoplastic Humans Integrin beta1 Intestinal Polyps Male Mice Mice, Knockout Neoplasm Staging Proteins rab GTP-Binding Proteins Smad3 Protein Tumor Suppressor Proteins

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