Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach.

Burclaff J, Osaki LH, Liu D, Goldenring JR, Mills JC
Gastroenterology. 2017 152 (4): 762-766.e7

PMID: 27932312 · PMCID: PMC5391042 · DOI:10.1053/j.gastro.2016.12.001

Parietal cell atrophy is considered to cause metaplasia in the stomach. We developed mice that express the diphtheria toxin receptor specifically in parietal cells to induce their death, and found this to increase proliferation in the normal stem cell zone and neck but not to cause metaplastic reprogramming of chief cells. Furthermore, the metaplasia-inducing agents tamoxifen or DMP-777 still induced metaplasia even after previous destruction of parietal cells by diphtheria toxin. Atrophy of parietal cells alone therefore is not sufficient to induce metaplasia: completion of metaplastic reprogramming of chief cells requires mechanisms beyond parietal cell injury or death.

Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

MeSH Terms (19)

Animals Apoptosis Atrophy Azetidines Cell Proliferation Cellular Reprogramming Chief Cells, Gastric Diphtheria Toxin Heparin-binding EGF-like Growth Factor Intercellular Signaling Peptides and Proteins Intrinsic Factor Metaplasia Mice Parietal Cells, Gastric Peptides Piperazines Plant Lectins Stomach Tamoxifen

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