Sex differences underlying pancreatic islet biology and its dysfunction.

Gannon M, Kulkarni RN, Tse HM, Mauvais-Jarvis F
Mol Metab. 2018 15: 82-91

PMID: 29891438 · PMCID: PMC6066785 · DOI:10.1016/j.molmet.2018.05.017

BACKGROUND - The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy.

SCOPE OF THE REVIEW - This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy.

MAJOR CONCLUSIONS - Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes.

Published by Elsevier GmbH.

MeSH Terms (6)

Animals Diabetes Mellitus Gonadal Hormones Humans Islets of Langerhans Sex Characteristics

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