Hak-Joon Sung
Assistant Professor of Biomedical Engineering, Assistant Professor of Medicine-Cardiovascular Medicine
Last active: 2/12/2015

ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.

Lee SH, Boire TC, Lee JB, Gupta MK, Zachman AL, Rath R, Sung HJ
J Mater Chem B. 2014 2 (41): 7109-7113

PMID: 25343029 · PMCID: PMC4203664 · DOI:10.1039/C4TB01094A

A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KPK. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis , indicating its unique advantages for tissue engineering applications.

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