Kevin Ess
Assistant Professor of Neurology
Last active: 2/16/2016

Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex.

Ess KC, Kamp CA, Tu BP, Gutmann DH
Neurology. 2005 64 (8): 1446-9

PMID: 15851742 · DOI:10.1212/01.WNL.0000158653.81008.49

Children with tuberous sclerosis complex (TSC) harbor developmental brain abnormalities (cortical tubers) and low-grade tumors (subependymal giant cell astrocytomas [SEGAs]). Using gene expression profiling to identify neuroglial differentiation markers in Tsc1 conditional knockout mice, the authors demonstrate that giant cells of SEGAs aberrantly express similar neuroglial differentiation markers as do cortical tubers. These results suggest that both tubers and SEGAs result from related defects in progenitor cell differentiation during brain development.

MeSH Terms (23)

Adolescent Animals Astrocytoma Brain Neoplasms Cell Differentiation Cell Lineage Child Disease Models, Animal Female Gene Expression Profiling Gene Expression Regulation, Developmental Genetic Markers Humans Infant Male Mice Mice, Knockout Nerve Tissue Proteins Neurons Stem Cells Tuberous Sclerosis Tuberous Sclerosis Complex 1 Protein Tumor Suppressor Proteins

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