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Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

Lutterbach B, Hiebert SW
Gene. 2000 245 (2): 223-35

PMID: 10717473 · DOI:10.1016/s0378-1119(00)00014-7

Chromosomal translocations affecting the AML-1 gene are among the most frequent aberrations found in acute leukemia. Because the AML-1 transcription factor is a critical regulator of hematopoeitic cell development, normal homeostasis is disrupted in cells containing these translocations. In this review we describe the mechanisms of transcriptional activation and repression by AML-1 and how this transcriptional control is disrupted by the chromosomal translocations that affect AML-1. Finally, we discuss how the mechanism of transcriptional repression by these chromosomal translocation fusion proteins is a possible target of therapeutic intervention in acute leukemia.

MeSH Terms (11)

Acute Disease Cell Differentiation Core Binding Factor Alpha 2 Subunit DNA-Binding Proteins Gene Expression Regulation, Neoplastic Hematopoietic Stem Cells Humans Leukemia, Myeloid Proto-Oncogene Proteins Transcription Factors Translocation, Genetic

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