, a bio/informatics shared resource is still "open for business" - Visit the CDS website

Scott Baldwin
Katrina Overall McDonald Professor of Pediatrics
Last active: 1/17/2012

Emulation of conduction system functions in the hearts of early mammalian embryos.

Lloyd TR, Baldwin HS
Pediatr Res. 1990 28 (5): 425-8

PMID: 2255564 · DOI:10.1203/00006450-199011000-00001

The conduction system functions of atrioventricular sequential contractions, atrioventricular delay, and coordination of ventricular contraction were examined in rat embryos at the earliest functional stage of cardiac development (before cardiac looping, n = 6) and shortly after looping (n = 15). Atrioventricular sequential contractions were observed in all embryos, and contractions appeared to originate in the left sinus horn. Atrioventricular delay was present in both prelooped (132 +/- 32 ms) and looped (141 +/- 15 ms) hearts. Before looping, contractions traveled from proximal ventricle to bulbus cordis, a distance of 253 +/- 27 microns, in 72 +/- 22 ms. After looping, contractions crossed an increased intraventricular distance (520 +/- 28 microns, p less than 0.005) in substantially less time (16 +/- 7 ms, p less than 0.005). Sinoatrial and atrioventricular nodal functions are emulated in both prelooped and looped hearts of early mammalian embryos, and His-Purkinje system function is emulated in looped hearts.

MeSH Terms (11)

Animals Atrial Function Fetal Heart Heart Atria Heart Conduction System Heart Ventricles Myocardial Contraction Organ Culture Techniques Rats Rats, Inbred Strains Ventricular Function

Connections (2)

This publication is referenced by other Labnodes entities: