Charles Hong
Associate Professor of Medicine
Last active: 9/28/2016

Large-scale small-molecule screen using zebrafish embryos.

Hong CC
Methods Mol Biol. 2009 486: 43-55

PMID: 19347615 · DOI:10.1007/978-1-60327-545-3_4

Zebrafish represents a versatile model organism with many molecular, morphological, and physiological similarities to mammals. Importantly, zebrafish are readily susceptible to perturbations by small molecules, including numerous pharmaceuticals in clinical use. Given these qualities, plus their small size and transparency, zebrafish embryos can be utilized for large-scale phenotype-based screens for small-molecule modifiers of biological processes. Thus, in a manner analogous to classical genetic screens, zebrafish chemical screens have the potential to reveal novel insights into complex biological pathways, as well as to identify lead compounds for novel therapeutics.

MeSH Terms (5)

Animals Drug Evaluation, Preclinical Embryo, Nonmammalian Small Molecule Libraries Zebrafish

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