Profile

Dr. Mark A. Magnuson is the Louise B. McGavock Professor of Molecular Physiology and Biophysics, Medicine, and Cell and Developmental Biology at Vanderbilt University. 

Dr. Magnuson graduated from Luther College in 1975 and obtained his medical degree from the University of Iowa in 1979.  He then did a residency in Internal Medicine at Strong Memorial Hospital at the University of Rochester before going to the NIH to obtain research training.  Following this he moved to Vanderbilt where he obtained additional research training in Molecular Physiology and clinical training in Endocrinology.  Dr. Magnuson became a Vanderbilt faculty member in 1987. 

Dr. Magnuson has authored or co-authored over 200 peer-reviewed articles.  He has been a member of numerous scientific review panels and has served on the editorial boards for Diabetes, Molecular Endocrinology and the Journal of Biological Chemistry, and has served as Associate Editor for both the American Journal of Physiology: Endocrinology and Metabolism and Experimental Biology and Medicine.  In 2006 he received the Sidney P. Colowick Faculty Award at Vanderbilt.  His research has been funded by the National Institutes of Health for over 25 years.  

Dr. Magnuson is currently Director of both the Vanderbilt Center for Stem Cell Biology and the Transgenic Mouse/ES Cell Shared Resource.  Between 1998 and 2005 he served as Director of the Office of Biomedical Sciences and Assistant Vice Chancellor for Research.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. FUCCI tracking shows cell-cycle-dependent Neurog3 variation in pancreatic progenitors. Bechard ME, Bankaitis ED, Ustione A, Piston DW, Magnuson MA, Wright CVE (2017) Genesis
    › Primary publication · 28772022 (PubMed)
  2. Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning. Spaeth JM, Gupte M, Perelis M, Yang YP, Cyphert H, Guo S, Liu JH, Guo M, Bass J, Magnuson MA, Wright C, Stein R (2017) Diabetes
    › Primary publication · 28705881 (PubMed)
  3. Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA (2017) Diabetes
    › Primary publication · 28550109 (PubMed)
  4. Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis. Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E (2017) Cell Death Differ
    › Primary publication · 28211872 (PubMed)
  5. c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis. Sánchez-Arévalo Lobo VJ, Fernández LC, Carrillo-de-Santa-Pau E, Richart L, Cobo I, Cendrowski J, Moreno U, Del Pozo N, Megías D, Bréant B, Wright CV, Magnuson M, Real FX (2017) Gut
    › Primary publication · 28159836 (PubMed)
  6. The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine-cell specification and postnatal β-cell maturation. Yang YP, Magnuson MA, Stein R, Wright CV (2016) Development
    › Primary publication · 27993987 (PubMed)
  7. Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Osipovich AB, Gangula R, Vianna PG, Magnuson MA (2016) Development 143(24): 4595-4607
    › Primary publication · 27864380 (PubMed)
  8. Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming. Clayton HW, Osipovich AB, Stancill JS, Schneider JD, Vianna PG, Shanks CM, Yuan W, Gu G, Manduchi E, Stoeckert CJ, Magnuson MA (2016) Cell Rep 17(8): 2028-2041
    › Primary publication · 27851966 (PubMed) · PMC5131369 (PubMed Central)
  9. Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A. Hoang CQ, Hale MA, Azevedo-Pouly AC, Elsässer HP, Deering TG, Willet SG, Pan FC, Magnuson MA, Wright CV, Swift GH, MacDonald RJ (2016) Mol Cell Biol 36(24): 3033-3047
    › Primary publication · 27697859 (PubMed) · PMC5126291 (PubMed Central)
  10. Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells. Bechard ME, Bankaitis ED, Hipkens SB, Ustione A, Piston DW, Yang YP, Magnuson MA, Wright CV (2016) Genes Dev 30(16): 1852-65
    › Primary publication · 27585590 (PubMed) · PMC5024683 (PubMed Central)
  11. p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network. Marshall CB, Mays DJ, Beeler JS, Rosenbluth JM, Boyd KL, Santos Guasch GL, Shaver TM, Tang LJ, Liu Q, Shyr Y, Venters BJ, Magnuson MA, Pietenpol JA (2016) Cell Rep 14(10): 2289-300
    › Primary publication · 26947080 (PubMed) · PMC4794398 (PubMed Central)
  12. mTORC2 regulates cardiac response to stress by inhibiting MST1. Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H, Sadoshima J (2015) Cell Rep 11(1): 125-36
    › Primary publication · 25843706 (PubMed) · PMC4417361 (PubMed Central)
  13. Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression. Brouwers B, de Faudeur G, Osipovich AB, Goyvaerts L, Lemaire K, Boesmans L, Cauwelier EJ, Granvik M, Pruniau VP, Van Lommel L, Van Schoors J, Stancill JS, Smolders I, Goffin V, Binart N, in't Veld P, Declercq J, Magnuson MA, Creemers JW, Schuit F, Schraenen A (2014) Cell Metab 20(6): 979-90
    › Primary publication · 25470546 (PubMed)
  14. Dominant and context-specific control of endodermal organ allocation by Ptf1a. Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV (2014) Development 141(22): 4385-94
    › Primary publication · 25371369 (PubMed) · PMC4302917 (PubMed Central)
  15. Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ, Takada S, Magnuson MA (2014) Development 141(15): 2939-49
    › Primary publication · 25053427 (PubMed) · PMC4197673 (PubMed Central)
  16. The MafA transcription factor becomes essential to islet β-cells soon after birth. Hang Y, Yamamoto T, Benninger RK, Brissova M, Guo M, Bush W, Piston DW, Powers AC, Magnuson M, Thurmond DC, Stein R (2014) Diabetes 63(6): 1994-2005
    › Primary publication · 24520122 (PubMed) · PMC4030115 (PubMed Central)
  17. Cytokine-driven beta-cell production in vivo. Worchel HN, Magnuson MA (2014) Nat Biotechnol 32(1): 63-4
    › Primary publication · 24406931 (PubMed)
  18. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, Hija A, Stolovich-Rain M, Furth-Lavi J, Granot Z, Porat S, Philipson LH, Herold KC, Bhatti TR, Stanley C, Ashcroft FM, In't Veld P, Saada A, Magnuson MA, Glaser B, Dor Y (2014) Cell Metab 19(1): 109-21
    › Primary publication · 24332968 (PubMed)
  19. Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Balderes DA, Magnuson MA, Sussel L (2013) Genesis 51(12): 844-51
    › Primary publication · 23996959 (PubMed) · PMC3902634 (PubMed Central)
  20. Pancreas-specific Cre driver lines and considerations for their prudent use. Magnuson MA, Osipovich AB (2013) Cell Metab 18(1): 9-20
    › Primary publication · 23823474 (PubMed) · PMC3732107 (PubMed Central)
  21. The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A (2013) EMBO J 32(10): 1393-408
    › Primary publication · 23584530 (PubMed) · PMC3655467 (PubMed Central)
  22. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M (2013) PLoS Genet 9(1): e1003274
    › Primary publication · 23382704 (PubMed) · PMC3561089 (PubMed Central)
  23. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV (2013) Development 140(4): 751-64
    › Primary publication · 23325761 (PubMed) · PMC3557774 (PubMed Central)
  24. Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L (2012) PLoS One 7(12): e52026
    › Primary publication · 23251675 (PubMed) · PMC3520898 (PubMed Central)
  25. Dual lineage-specific expression of Sox17 during mouse embryogenesis. Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ, Grapin-Botton A, Magnuson MA (2012) Stem Cells 30(10): 2297-308
    › Primary publication · 22865702 (PubMed) · PMC3448801 (PubMed Central)
  26. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM (2009) Cancer Cell 15(2): 148-59
    › Primary publication · 19185849 (PubMed) · PMC2701381 (PubMed Central)
  27. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA (2008) Dev Biol 316(1): 74-86
    › Primary publication · 18294628 (PubMed) · PMC2425677 (PubMed Central)
  28. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA (2006) Dev Cell 11(4): 583-9
    › Primary publication · 16962829 (PubMed)
  29. Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection. Long Q, Shelton KD, Lindner J, Jones JR, Magnuson MA (2004) Genesis 39(4): 256-62
    › Primary publication · 15286998 (PubMed)
  30. Allosteric activators of glucokinase: potential role in diabetes therapy. Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF (2003) Science 301(5631): 370-3
    › Primary publication · 12869762 (PubMed)
  31. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR (1999) Cell 96(3): 329-39
    › Primary publication · 10025399 (PubMed)
  32. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV (1996) Development 122(3): 983-95
    › Primary publication · 8631275 (PubMed)