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Chiyo Shiota, Ph.D.

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Research Instructor, 1997-2005.

Publications

The following timeline graph is generated from all co-authored publications.

  1. Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence. Zelent B, Odili S, Buettger C, Shiota C, Grimsby J, Taub R, Magnuson MA, Vanderkooi JM, Matschinsky FM (2008) Biochem J 413(2): 269-80
    › Primary publication · 18370929 (PubMed)
  2. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA (2006) Dev Cell 11(4): 583-9
    › Primary publication · 16962829 (PubMed)
  3. Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor. Shiota C, Rocheleau JV, Shiota M, Piston DW, Magnuson MA (2005) Am J Physiol Endocrinol Metab 289(4): E570-7
    › Primary publication · 15941784 (PubMed)
  4. Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young. Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM (2005) J Biol Chem 280(14): 14105-13
    › Primary publication · 15677479 (PubMed)
  5. Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. Gloyn AL, Noordam K, Willemsen MA, Ellard S, Lam WW, Campbell IW, Midgley P, Shiota C, Buettger C, Magnuson MA, Matschinsky FM, Hattersley AT (2003) Diabetes 52(9): 2433-40
    › Primary publication · 12941786 (PubMed)
  6. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. Shiota C, Larsson O, Shelton KD, Shiota M, Efanov AM, Hoy M, Lindner J, Kooptiwut S, Juntti-Berggren L, Gromada J, Berggren PO, Magnuson MA (2002) J Biol Chem 277(40): 37176-83
    › Primary publication · 12149271 (PubMed)
  7. The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy. Christesen HB, Jacobsen BB, Odili S, Buettger C, Cuesta-Munoz A, Hansen T, Brusgaard K, Massa O, Magnuson MA, Shiota C, Matschinsky FM, Barbetti F (2002) Diabetes 51(4): 1240-6
    › Primary publication · 11916951 (PubMed)
  8. Characterization of glucokinase regulatory protein-deficient mice. Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF (2000) J Biol Chem 275(11): 7826-31
    › Primary publication · 10713097 (PubMed)
  9. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Gannon M, Shiota C, Postic C, Wright CV, Magnuson M (2000) Genesis 26(2): 139-42
    › Primary publication · 10686610 (PubMed)
  10. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. Shiota C, Coffey J, Grimsby J, Grippo JF, Magnuson MA (1999) J Biol Chem 274(52): 37125-30
    › Primary publication · 10601273 (PubMed)

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    Contact Information

    Rangos Research Center Room 8116 University of Pittsburgh 3460 Fifth Avenue
    Pittsburgh, PA 15213
    412-692-7920 (p)
    412-692-3466 (f)
    Email

    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    Alleles Animals Binding Sites Biological Transport Blood Glucose Child Cloning, Molecular Diabetes Mellitus Diabetes Mellitus, Type 2 Diazoxide Enzyme Stability Fetal Development Glucokinase Glucose Clamp Technique Homeostasis Hyperglycemia Insulin Kinetics Mice, Knockout Molecular Conformation Multidrug Resistance-Associated Proteins Phenotype Point Mutation Pregnancy Promoter Regions, Genetic Protein Structure, Tertiary Rapamycin-Insensitive Companion of mTOR Protein Rats Sulfonylurea Receptors TOR Serine-Threonine Kinases