Erin Sparks
Last active: 3/7/2011

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Erin E Sparks, B.S.

Profile

Erin E. Sparks is a graduate student in Dr. Huppert’s lab. Erin graduated from Northwestern University in 2004 with a degree in Biomedical Engineering specializing in Transport Processes and Tissue Engineering. As an undergraduate she received awards for her senior design project to design a bone clamp for use in orthopedic surgery, which is in the process of being patented. She also worked in Dr. H. William Schnaper’s lab in Pediatric Nephrology and stayed on as a research technologist for 2 years after graduation. In Dr. Schnaper’s lab she investigated the crosstalk between TGF-Beta and cytoskeletal signaling in human kidney mesangial cells as it pertains to glomerulosclerosis. In the fall of 2007, Erin matriculated in the IGP program at Vanderbilt and subsequently joined the Huppert lab. Currently Erin is working to elucidate mechanisms of liver biliary development and signaling pathways that contribute to bile duct epithelial cell specification.

Publications

The following timeline graph is generated from all co-authored publications.

Most recent publication(s) are shown below:

  1. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS (2011) Dis Model Mech 4(3): 359-67
    › Primary publication · 21282722 (PubMed) · PMC3097457 (PubMed Central)
  2. Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Sparks EE, Huppert KA, Brown MA, Washington MK, Huppert SS (2010) Hepatology 51(4): 1391-400
    › Primary publication · 20069650 (PubMed) · PMC2995854 (PubMed Central)
  3. Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism. Hubchak SC, Sparks EE, Hayashida T, Schnaper HW (2009) Am J Physiol Renal Physiol 297(5): F1316-23
    › Primary publication · 19726546 (PubMed) · PMC2781339 (PubMed Central)

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    Contact Information

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    615-936-7391 (p)
    615-322-6645 (f)
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    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    Actins Aging Animals Bile Ducts, Intrahepatic Blotting, Northern Cell Communication Collagen Type I Fibrosis Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein Keratin-19 Kidney Kidney Cortex Mice Mice, Knockout Morphogenesis Oncogene Protein v-akt Phosphatidylinositol 3-Kinases Plasmids rac1 GTP-Binding Protein Receptor, Notch1 Receptor, Notch2 Receptors, Notch rhoA GTP-Binding Protein rho GTP-Binding Proteins RNA Signal Transduction Tomography, X-Ray Computed Transfection Transforming Growth Factor beta