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Dr. Stacey S. Huppert joined the Vanderbilt Center for Stem Cell Biology (VCSCB) in October of 2005 as its first faculty recruit. Stacey earned her doctorate in genetics from Indiana University in the Laboratory of Marc A. T. Muskavitch. Her thesis work demonstrated that Notch signaling exerts feedback regulation on ligand and receptor expression, and that the resultant asymmetries underlie proper cell fate determination. She continued to study Notch signaling mechanisms with Raphael Kopan, first as a postdoctoral fellow, then as an Instructor in the Department of Molecular Biology and Pharmacology at Washington University School of Medicine. Dr. Huppert’s research program will focus on exploring how intercellular signaling pathways are integrated in both developmental and disease responses of the liver. She will explore the role of Notch in liver organogenesis and regeneration in order to better understand the role of progenitor/stem cells in hepatocyte cell population maintenance and renewal.
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Key: MeSH Term KeywordAmino Acid Sequence Amyloid Precursor Protein Secretases Animals, Newborn Body Patterning cancer cell fate determination cell signaling Cholestasis developmental biology Ectoderm Embryo, Mammalian embryonic stem cell differentiation Endopeptidases Endothelium Feedback Fetal Heart Fibroblasts Flavones Gene Deletion genetics Glutamate-Ammonia Ligase Hedgehog Proteins HeLa Cells Heparan Sulfate Proteoglycans Hepatocyte Nuclear Factor 4 Hepatocytes Histone Deacetylases Hypoglycemia Integrases liver disease liver regeneration Liver Regeneration Methionine Mice, Inbred Strains Mice, Mutant Strains Models, Biological mouse knockouts and transgenics notch pathway organ cultures Serine Endopeptidases Serrate-Jagged Proteins signal transduction stem cell biology