Rafael Arrojo e Drigo, Ph.D.

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Publications

The following timeline graph is generated from all co-authored publications.

1. Molecular and functional profiling of human islets: from heterogeneity to human phenotypes. Arrojo E Drigo R, Roy B, MacDonald PE (2020) Diabetologia 63(10): 2095-2101
   › Primary publication · 32894320 (PubMed)
2. Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease. Bersini S, Arrojo E Drigo R, Huang L, Shokhirev MN, Hetzer MW (2020) Adv Biosyst 4(5): e2000044
   › Primary publication · 32402127 (PubMed)
3. Structural basis for delta cell paracrine regulation in pancreatic islets. Arrojo E Drigo R, Jacob S, García-Prieto CF, Zheng X, Fukuda M, Nhu HTT, Stelmashenko O, Peçanha FLM, Rodriguez-Diaz R, Bushong E, Deerinck T, Phan S, Ali Y, Leibiger I, Chua M, Boudier T, Song SH, Graf M, Augustine GJ, Ellisman MH, Berggren PO (2019) Nat Commun 10(1): 3700
   › Primary publication · 31420552 (PubMed) · PMC6697679 (PubMed Central)
4. Age Mosaicism across Multiple Scales in Adult Tissues. Arrojo E Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E, Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer MW (2019) Cell Metab 30(2): 343-351.e3
   › Primary publication · 31178361 (PubMed) · PMC7289515 (PubMed Central)
5. Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. Toyama BH, Arrojo E Drigo R, Lev-Ram V, Ramachandra R, Deerinck TJ, Lechene C, Ellisman MH, Hetzer MW (2019) J Cell Biol 218(2): 433-444
   › Primary publication · 30552100 (PubMed) · PMC6363465 (PubMed Central)
6. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N (2018) Nat Med 24(1): 39-49
   › Primary publication · 29200204 (PubMed) · PMC5760280 (PubMed Central)
7. Pancreatic Islet Blood Flow Dynamics in Primates. Diez JA, Arrojo E Drigo R, Zheng X, Stelmashenko OV, Chua M, Rodriguez-Diaz R, Fukuda M, Köhler M, Leibiger I, Tun SBB, Ali Y, Augustine GJ, Barathi VA, Berggren PO (2017) Cell Rep 20(6): 1490-1501
   › Primary publication · 28793270 (PubMed) · PMC5575201 (PubMed Central)
8. A novel toolbox to investigate tissue spatial organization applied to the study of the islets of Langerhans. Tran Thi Nhu H, Arrojo E Drigo R, Berggren PO, Boudier T (2017) Sci Rep : 44261
   › Primary publication · 28303903 (PubMed) · PMC5355872 (PubMed Central)
9. New insights into the architecture of the islet of Langerhans: a focused cross-species assessment. Arrojo e Drigo R, Ali Y, Diez J, Srinivasan DK, Berggren PO, Boehm BO (2015) Diabetologia 58(10): 2218-28
   › Primary publication · 26215305 (PubMed)
10. Young capillary vessels rejuvenate aged pancreatic islets. Almaça J, Molina J, Arrojo E Drigo R, Abdulreda MH, Jeon WB, Berggren PO, Caicedo A, Nam HG (2014) Proc Natl Acad Sci U S A 111(49): 17612-7
    › Primary publication · 25404292 (PubMed) · PMC4267392 (PubMed Central)
11. The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. Arrojo E Drigo R, Egri P, Jo S, Gereben B, Bianco AC (2013) Mol Endocrinol 27(12): 2105-15
    › Primary publication · 24196352 (PubMed) · PMC3857201 (PubMed Central)
12. Coordination of hypothalamic and pituitary T3 production regulates TSH expression. Fonseca TL, Correa-Medina M, Campos MP, Wittmann G, Werneck-de-Castro JP, Arrojo e Drigo R, Mora-Garzon M, Ueta CB, Caicedo A, Fekete C, Gereben B, Lechan RM, Bianco AC (2013) J Clin Invest 123(4): 1492-500
    › Primary publication · 23524969 (PubMed) · PMC3613903 (PubMed Central)
13. Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Arrojo E Drigo R, Fonseca TL, Werneck-de-Castro JP, Bianco AC (2013) Biochim Biophys Acta 1830(7): 3956-64
    › Primary publication · 22967761 (PubMed) · PMC4979226 (PubMed Central)
14. Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC (2012) J Neurosci 32(25): 8491-500
    › Primary publication · 22723689 (PubMed) · PMC3752066 (PubMed Central)
15. A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. Kalló I, Mohácsik P, Vida B, Zeöld A, Bardóczi Z, Zavacki AM, Farkas E, Kádár A, Hrabovszky E, Arrojo E Drigo R, Dong L, Barna L, Palkovits M, Borsay BA, Herczeg L, Lechan RM, Bianco AC, Liposits Z, Fekete C, Gereben B (2012) PLoS One 7(6): e37860
    › Primary publication · 22719854 (PubMed) · PMC3377717 (PubMed Central)
16. Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Mohácsik P, Gereben B, Bianco AC (2011) Mol Endocrinol 25(12): 2065-75
    › Primary publication · 22053000 (PubMed) · PMC3231828 (PubMed Central)
17. Type 2 deiodinase at the crossroads of thyroid hormone action. Arrojo E Drigo R, Bianco AC (2011) Int J Biochem Cell Biol 43(10): 1432-41
    › Primary publication · 21679772 (PubMed) · PMC3163779 (PubMed Central)
18. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC (2011) FEBS Lett 585(3): 539-44
    › Primary publication · 21237159 (PubMed) · PMC3133948 (PubMed Central)
19. Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment. Rosene ML, Wittmann G, Arrojo e Drigo R, Singru PS, Lechan RM, Bianco AC (2010) Endocrinology 151(12): 5961-70
    › Primary publication · 20926587 (PubMed) · PMC2999495 (PubMed Central)
20. Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells. Aerts G, Arrojo E Drigo R, Van Herck SL, Sammels E, Mirebeau-Prunier D, Gereben B, Zeöld A, Harney JW, Huang SA, Mulcahey MA, Van der Geyten S, Van den Bergh G, Arckens L, Darras VM, Zavacki AM (2009) Endocrinology 150(11): 5171-80
    › Primary publication · 19819956 (PubMed) · PMC2775988 (PubMed Central)
21. The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Zavacki AM, Arrojo E Drigo R, Freitas BC, Chung M, Harney JW, Egri P, Wittmann G, Fekete C, Gereben B, Bianco AC (2009) Mol Cell Biol 29(19): 5339-47
    › Primary publication · 19651899 (PubMed) · PMC2747977 (PubMed Central)
22. Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations. Christoffolete MA, Arrojo e Drigo R, Gazoni F, Tente SM, Goncalves V, Amorim BS, Larsen PR, Bianco AC, Zavacki AM (2007) Endocrinology 148(3): 954-60
    › Primary publication · 17138654 (PubMed)

Keywords & MeSH Terms

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