, a bio/informatics shared resource is still "open for business" - Visit the CDS website


Lars Plate
Last active: 3/3/2020

Profile

None provided

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P (2019) Elife
    › Primary publication · 31149896 (PubMed) · PMC6588346 (PubMed Central)
  2. Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein. Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL (2019) Cell Chem Biol 26(7): 913-925.e4
    › Primary publication · 31105062 (PubMed) · PMC6642020 (PubMed Central)
  3. Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing. Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL (2019) ACS Chem Biol 14(4): 784-795
    › Primary publication · 30821953 (PubMed) · PMC6474822 (PubMed Central)
  4. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC (2019) Nat Commun 10(1): 187
    › Primary publication · 30643122 (PubMed) · PMC6331617 (PubMed Central)
  5. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW (2018) Elife
    › Primary publication · 30084354 (PubMed) · PMC6080950 (PubMed Central)
  6. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH (2018) Sci Signal 11(517)
    › Primary publication · 29440509 (PubMed) · PMC5957084 (PubMed Central)
  7. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW (2018) J Am Chem Soc 140(1): 200-210
    › Primary publication · 29265822 (PubMed) · PMC5762408 (PubMed Central)
  8. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW (2017) Sci Transl Med 9(407)
    › Primary publication · 28904227 (PubMed) · PMC5628019 (PubMed Central)
  9. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL (2017) EMBO J 36(15): 2296-2309
    › Primary publication · 28655754 (PubMed) · PMC5538767 (PubMed Central)
  10. Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy. Plate L, Wiseman RL (2017) Trends Cell Biol 27(10): 722-737
    › Primary publication · 28647092 (PubMed) · PMC5612838 (PubMed Central)
  11. Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis. Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK (2017) Arthritis Rheumatol 69(7): 1418-1428
    › Primary publication · 28334504 (PubMed) · PMC5489357 (PubMed Central)
  12. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW (2016) Elife
    › Primary publication · 27435961 (PubMed) · PMC4954754 (PubMed Central)
  13. Modulating protein quality control. Plate L, Paxman RJ, Wiseman RL, Kelly JW (2016) Elife
    › Primary publication · 27435959 (PubMed) · PMC4954752 (PubMed Central)
  14. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue. Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW (2016) J Am Chem Soc 138(23): 7353-64
    › Primary publication · 27191344 (PubMed) · PMC4909538 (PubMed Central)
  15. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL (2014) Proc Natl Acad Sci U S A 111(36): 13046-51
    › Primary publication · 25157167 (PubMed) · PMC4246986 (PubMed Central)
  16. Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network. Plate L, Marletta MA (2013) Proc Natl Acad Sci U S A 110(48): E4648-57
    › Primary publication · 24218564 (PubMed) · PMC3845109 (PubMed Central)
  17. Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior. Plate L, Marletta MA (2013) Trends Biochem Sci 38(11): 566-75
    › Primary publication · 24113192 (PubMed) · PMC3819143 (PubMed Central)
  18. Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism. Ivanisevic J, Zhu ZJ, Plate L, Tautenhahn R, Chen S, O'Brien PJ, Johnson CH, Marletta MA, Patti GJ, Siuzdak G (2013) Anal Chem 85(14): 6876-84
    › Primary publication · 23781873 (PubMed) · PMC3761963 (PubMed Central)
  19. Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. Plate L, Marletta MA (2012) Mol Cell 46(4): 449-60
    › Primary publication · 22542454 (PubMed) · PMC3361614 (PubMed Central)