Dane Chetkovich
Last active: 4/2/2019


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The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Pannexin1 as a Possible Panacea for Intractable Epilepsy. Lyman KA, Chetkovich DM (2018) Epilepsy Curr 18(6): 396-397
    › Primary publication · 30568560 (PubMed) · PMC6278739 (PubMed Central)
  2. Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. Ou-Yang MH, Kurz JE, Nomura T, Popovic J, Rajapaksha TW, Dong H, Contractor A, Chetkovich DM, Tourtellotte WG, Vassar R (2018) Sci Transl Med 10(459)
    › Primary publication · 30232227 (PubMed)
  3. HCN channels in the hippocampus regulate active coping behavior. Fisher DW, Han Y, Lyman KA, Heuermann RJ, Bean LA, Ybarra N, Foote KM, Dong H, Nicholson DA, Chetkovich DM (2018) J Neurochem 146(6): 753-766
    › Primary publication · 29953635 (PubMed) · PMC6158061 (PubMed Central)
  4. Molecular Mimicry may Underlie a Worm-Associated Epilepsy Syndrome. Lyman KA, Chetkovich DM (2018) Epilepsy Curr 18(3): 180-181
    › Primary publication · 29950943 (PubMed) · PMC6017679 (PubMed Central)
  5. Publisher Correction: Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive. Yun S, Reynolds RP, Petrof I, White A, Rivera PD, Segev A, Gibson AD, Suarez M, DeSalle MJ, Ito N, Mukherjee S, Richardson DR, Kang CE, Ahrens-Nicklas RC, Soler I, Chetkovich DM, Kourrich S, Coulter DA, Eisch AJ (2018) Nat Med 24(9): 1482
    › Primary publication · 29934536 (PubMed)
  6. Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease. Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Justus D, Neuman KM, Ayala GD, Mullen SA, Voskobiynyk Y, Tulisiak CT, Fels JA, Corbett NJ, Carballo G, Kennedy CD, Popovic J, Ramos-Franco J, Fill M, Pergande MR, Borgia JA, Corbett GT, Pahan K, Han Y, Chetkovich DM, Vassar RJ, Byrne RW, Matthew Oh M, Stoub TR, Remy S, Disterhoft JF, Nicholson DA (2018) Neurobiol Learn Mem : 141-157
    › Primary publication · 29906573 (PubMed) · PMC6434702 (PubMed Central)
  7. Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive. Yun S, Reynolds RP, Petrof I, White A, Rivera PD, Segev A, Gibson AD, Suarez M, DeSalle MJ, Ito N, Mukherjee S, Richardson DR, Kang CE, Ahrens-Nicklas RC, Soler I, Chetkovich DM, Kourrich S, Coulter DA, Eisch AJ (2018) Nat Med 24(5): 658-666
    › Primary publication · 29662202 (PubMed) · PMC5948139 (PubMed Central)
  8. Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice. Fisher DW, Luu P, Agarwal N, Kurz JE, Chetkovich DM (2018) PLoS One 13(2): e0193012
    › Primary publication · 29466436 (PubMed) · PMC5821371 (PubMed Central)
  9. Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Frigerio F, Flynn C, Han Y, Lyman K, Lugo JN, Ravizza T, Ghestem A, Pitsch J, Becker A, Anderson AE, Vezzani A, Chetkovich D, Bernard C (2018) Mol Neurobiol 55(9): 7500-7511
    › Primary publication · 29427087 (PubMed) · PMC6070409 (PubMed Central)
  10. Understanding Network Connections Connects Genotype to Epilepsy Phenotype. Kurz JE, Chetkovich DM (2017) Epilepsy Curr 17(4): 239-240
    › Primary publication · 29225532 (PubMed) · PMC5716121 (PubMed Central)
  11. Excitatory Synaptic Input to Hilar Mossy Cells under Basal and Hyperexcitable Conditions. Hedrick TP, Nobis WP, Foote KM, Ishii T, Chetkovich DM, Swanson GT (2017) eNeuro 4(6)
    › Primary publication · 29214210 (PubMed) · PMC5714709 (PubMed Central)
  12. Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels. Zobeiri M, Chaudhary R, Datunashvili M, Heuermann RJ, Lüttjohann A, Narayanan V, Balfanz S, Meuth P, Chetkovich DM, Pape HC, Baumann A, van Luijtelaar G, Budde T (2018) Brain Struct Funct 223(3): 1537-1564
    › Primary publication · 29168010 (PubMed) · PMC5869905 (PubMed Central)
  13. Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels. Lyman KA, Han Y, Heuermann RJ, Cheng X, Kurz JE, Lyman RE, Van Veldhoven PP, Chetkovich DM (2017) J Biol Chem 292(43): 17718-17730
    › Primary publication · 28887304 (PubMed) · PMC5663874 (PubMed Central)
  14. New Insights Into Postictal Paresis: An Epilepsy-Associated Phenomenon That may not be as Benign as Long Thought. Lyman KA, Chetkovich D (2017) Epilepsy Curr 17(3): 167-168
    › Primary publication · 28684952 (PubMed) · PMC5486427 (PubMed Central)
  15. Mutant IDH1 and seizures in patients with glioma. Chen H, Judkins J, Thomas C, Wu M, Khoury L, Benjamin CG, Pacione D, Golfinos JG, Kumthekar P, Ghamsari F, Chen L, Lein P, Chetkovich DM, Snuderl M, Horbinski C (2017) Neurology 88(19): 1805-1813
    › Primary publication · 28404805 (PubMed) · PMC5419985 (PubMed Central)
  16. Animal models suggest the TRIP8b-HCN interaction is a therapeutic target for major depressive disorder. Lyman KA, Han Y, Chetkovich DM (2017) Expert Opin Ther Targets 21(3): 235-237
    › Primary publication · 28127990 (PubMed) · PMC5546004 (PubMed Central)
  17. Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b. Han Y, Lyman KA, Clutter M, Schiltz GE, Ismail QA, Cheng X, Luan CH, Chetkovich DM (2016) J Vis Exp (117)
    › Primary publication · 27911380 (PubMed) · PMC5145243 (PubMed Central)
  18. HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects. Han Y, Heuermann RJ, Lyman KA, Fisher D, Ismail QA, Chetkovich DM (2017) Mol Psychiatry 22(3): 458-465
    › Primary publication · 27400855 (PubMed) · PMC5233690 (PubMed Central)
  19. Nurture Trumps Nature in a Model of Heritable Epilepsy: Will Bumetanide Be the First Antiepileptogenic Drug? Heuermann RJ, Chetkovich D (2016) Epilepsy Curr 16(3): 168-9
    › Primary publication · 27330444 (PubMed) · PMC4913850 (PubMed Central)
  20. A Time and Place for Everything: Early-Life Seizures at Different Developmental Epochs Have Distinct Effects on Adult Hippocampal Structure and Function. Kurz JE, Chetkovich DM (2016) Epilepsy Curr 16(2): 106-7
    › Primary publication · 27073344 (PubMed) · PMC4822729 (PubMed Central)
  21. Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy. Heuermann RJ, Jaramillo TC, Ying SW, Suter BA, Lyman KA, Han Y, Lewis AS, Hampton TG, Shepherd GMG, Goldstein PA, Chetkovich DM (2016) Neurobiol Dis : 81-92
    › Primary publication · 26459112 (PubMed) · PMC4688217 (PubMed Central)
  22. Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels. Han Y, Lyman K, Clutter M, Schiltz GE, Ismail QA, Prados DB, Luan CH, Chetkovich DM (2015) J Biomol Screen 20(9): 1124-31
    › Primary publication · 26045196 (PubMed) · PMC4755285 (PubMed Central)
  23. Cortical Compass: EML1 Helps Point the Way in Neuronal Migration. Lyman KA, Chetkovich DM (2015) Epilepsy Curr 15(1): 43-4
    › Primary publication · 25678890 (PubMed) · PMC4320960 (PubMed Central)
  24. Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels. Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, Bähring R, Bender RA (2014) FASEB J 28(5): 2177-90
    › Primary publication · 24451387 (PubMed)
  25. TRIP8b is required for maximal expression of HCN1 in the mouse retina. Pan Y, Bhattarai S, Modestou M, Drack AV, Chetkovich DM, Baker SA (2014) PLoS One 9(1): e85850
    › Primary publication · 24409334 (PubMed) · PMC3883711 (PubMed Central)
  26. Short- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b. Brager DH, Lewis AS, Chetkovich DM, Johnston D (2013) J Neurophysiol 110(10): 2350-7
    › Primary publication · 23966674 (PubMed) · PMC3841871 (PubMed Central)
  27. Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. Dougherty KA, Nicholson DA, Diaz L, Buss EW, Neuman KM, Chetkovich DM, Johnston D (2013) J Neurophysiol 109(7): 1940-53
    › Primary publication · 23324324 (PubMed) · PMC3628004 (PubMed Central)
  28. TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels. Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM (2012) J Neurosci 32(42): 14835-48
    › Primary publication · 23077068 (PubMed) · PMC4104472 (PubMed Central)
  29. Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels. Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN (2012) Proc Natl Acad Sci U S A 109(20): 7899-904
    › Primary publication · 22550182 (PubMed) · PMC3356637 (PubMed Central)
  30. Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C (2012) J Biol Chem 287(21): 17656-17661
    › Primary publication · 22511771 (PubMed) · PMC3366832 (PubMed Central)
  31. Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells. Marcelin B, Liu Z, Chen Y, Lewis AS, Becker A, McClelland S, Chetkovich DM, Migliore M, Baram TZ, Esclapez M, Bernard C (2012) J Neurosci 32(11): 3736-47
    › Primary publication · 22423094 (PubMed) · PMC3321843 (PubMed Central)
  32. Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms. Wilkars W, Liu Z, Lewis AS, Stoub TR, Ramos EM, Brandt N, Nicholson DA, Chetkovich DM, Bender RA (2012) PLoS One 7(2): e32181
    › Primary publication · 22363812 (PubMed) · PMC3283722 (PubMed Central)
  33. An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision. Khurana S, Liu Z, Lewis AS, Rosa K, Chetkovich D, Golding NL (2012) J Neurosci 32(8): 2814-23
    › Primary publication · 22357864 (PubMed) · PMC3342760 (PubMed Central)
  34. Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains. Kanyshkova T, Meuth P, Bista P, Liu Z, Ehling P, Caputi L, Doengi M, Chetkovich DM, Pape HC, Budde T (2012) Neurobiol Dis 45(1): 450-61
    › Primary publication · 21945537 (PubMed) · PMC3225716 (PubMed Central)
  35. Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. Lewis AS, Vaidya SP, Blaiss CA, Liu Z, Stoub TR, Brager DH, Chen X, Bender RA, Estep CM, Popov AB, Kang CE, Van Veldhoven PP, Bayliss DA, Nicholson DA, Powell CM, Johnston D, Chetkovich DM (2011) J Neurosci 31(20): 7424-40
    › Primary publication · 21593326 (PubMed) · PMC3169171 (PubMed Central)
  36. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM (2011) J Biol Chem 286(23): 20823-34
    › Primary publication · 21504900 (PubMed) · PMC3121500 (PubMed Central)
  37. HCN channels in behavior and neurological disease: too hyper or not active enough? Lewis AS, Chetkovich DM (2011) Mol Cell Neurosci 46(2): 357-67
    › Primary publication · 21130878 (PubMed) · PMC3073601 (PubMed Central)
  38. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Hitt BD, Jaramillo TC, Chetkovich DM, Vassar R (2010) Mol Neurodegener : 31
    › Primary publication · 20731874 (PubMed) · PMC2933677 (PubMed Central)
  39. Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. Noam Y, Zha Q, Phan L, Wu RL, Chetkovich DM, Wadman WJ, Baram TZ (2010) J Biol Chem 285(19): 14724-36
    › Primary publication · 20215108 (PubMed) · PMC2863223 (PubMed Central)
  40. Regulation of stargazin synaptic trafficking by C-terminal PDZ ligand phosphorylation in bidirectional synaptic plasticity. Stein EL, Chetkovich DM (2010) J Neurochem 113(1): 42-53
    › Primary publication · 19968761 (PubMed) · PMC4035483 (PubMed Central)
  41. Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM (2009) J Neurosci 29(19): 6250-65
    › Primary publication · 19439603 (PubMed) · PMC2730639 (PubMed Central)
  42. Thalamic reticular neurons are unexcited by new stargazer seizure mechanism. Chetkovich D (2009) Epilepsy Curr 9(2): 59-61
    › Primary publication · 19421384 (PubMed) · PMC2673410 (PubMed Central)
  43. Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Chung WK, Shin M, Jaramillo TC, Leibel RL, LeDuc CA, Fischer SG, Tzilianos E, Gheith AA, Lewis AS, Chetkovich DM (2009) Neurobiol Dis 33(3): 499-508
    › Primary publication · 19150498 (PubMed) · PMC2643333 (PubMed Central)
  44. Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy. Shin M, Brager D, Jaramillo TC, Johnston D, Chetkovich DM (2008) Neurobiol Dis 32(1): 26-36
    › Primary publication · 18657617 (PubMed) · PMC2626192 (PubMed Central)
  45. Activity-dependent regulation of h channel distribution in hippocampal CA1 pyramidal neurons. Shin M, Chetkovich DM (2007) J Biol Chem 282(45): 33168-80
    › Primary publication · 17848552 (PubMed) · PMC2685032 (PubMed Central)
  46. Evaluation of HCN2 abnormalities as a cause of juvenile audiogenic seizures in Black Swiss mice. Shin M, Simkin D, Suyeoka GM, Chetkovich DM (2006) Brain Res 1083(1): 14-20
    › Primary publication · 16542642 (PubMed)
  47. AMPA receptor synaptic targeting regulated by stargazin interactions with the Golgi-resident PDZ protein nPIST. Cuadra AE, Kuo SH, Kawasaki Y, Bredt DS, Chetkovich DM (2004) J Neurosci 24(34): 7491-502
    › Primary publication · 15329396 (PubMed) · PMC6729637 (PubMed Central)
  48. Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice. Misawa H, Sherr EH, Lee DJ, Chetkovich DM, Tan A, Schreiner CE, Bredt DS (2002) J Neurosci 22(23): 10088-93
    › Primary publication · 12451109 (PubMed) · PMC6758732 (PubMed Central)
  49. Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (2002) J Neurosci 22(15): 6415-25
    › Primary publication · 12151521 (PubMed) · PMC6758133 (PubMed Central)
  50. Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors. Chetkovich DM, Chen L, Stocker TJ, Nicoll RA, Bredt DS (2002) J Neurosci 22(14): 5791-6
    › Primary publication · 12122038 (PubMed) · PMC6757934 (PubMed Central)
  51. Deaths from stroke in US children, 1979 to 1998. Fullerton HJ, Chetkovich DM, Wu YW, Smith WS, Johnston SC (2002) Neurology 59(1): 34-9
    › Primary publication · 12105304 (PubMed)
  52. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA (2000) Nature 408(6815): 936-43
    › Primary publication · 11140673 (PubMed)
  53. PSD-95 involvement in maturation of excitatory synapses. El-Husseini AE, Schnell E, Chetkovich DM, Nicoll RA, Bredt DS (2000) Science 290(5495): 1364-8
    › Primary publication · 11082065 (PubMed)
  54. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. El-Husseini AE, Craven SE, Chetkovich DM, Firestein BL, Schnell E, Aoki C, Bredt DS (2000) J Cell Biol 148(1): 159-72
    › Primary publication · 10629226 (PubMed) · PMC2156213 (PubMed Central)
  55. nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase. Chetkovich DM, Sweatt JD (1993) J Neurochem 61(5): 1933-42
    › Primary publication · 7901336 (PubMed)
  56. Nitric oxide synthase-independent long-term potentiation in area CA1 of hippocampus. Chetkovich DM, Klann E, Sweatt JD (1993) Neuroreport 4(7): 919-22
    › Primary publication · 7690266 (PubMed)
  57. Ca(2+)-induced persistent protein kinase C activation in rat hippocampal homogenates. Sessoms JS, Chen SJ, Chetkovich DM, Powell CM, Roberson ED, Sweatt JD, Klann E (1992) Second Messengers Phosphoproteins 14(3): 109-26
    › Primary publication · 1345337 (PubMed)