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Edward Chaum
Last active: 6/11/2018

Profile

Dr. Chaum is a clinician scientist who specializes in all aspects of the medical and surgical management of retinal diseases, with particular interests in macular degeneration, diabetic retinopathy, translational bioengineering, and telemedicine. Dr. Chaum is the Margy Ann and J. Donald M. Gass Professor of Ophthalmology and Visual Sciences at the Vanderbilt Eye Institute and Professor of Pathology, Microbiology & Immunology, and Biomedical Engineering. He is the former University of Tennessee Plough Foundation Professor of Retinal Diseases. He obtained his undergraduate degree from Johns Hopkins University and both MD and PhD from Cornell University. He completed residencies in Pediatrics (Harvard) and Ophthalmology (Boston University) and received his Retina surgical training at the Massachusetts Eye and Ear Infirmary (Harvard). He is the recipient of numerous awards and distinctions throughout his academic career including; AΩA Honor Medical Society; National Eye Institute Research Career Award; Best Doctors in America®; Research to Prevent Blindness Senior Scientist Award; an R&D 100 Award, an American Telemedicine Association Innovation Award and others. He has 7 issued bioengineering patents and is a serial entrepreneur.

Dr. Chaum’s research focuses on translational biomedical and tissue engineering, telemedicine, and the application of biosensors and nanotechnology to clinical medicine and surgery.  He is the author of over 80 basic science papers, 5 book chapters, and a recent textbook in the fields of molecular biology, biomedical engineering, image analysis, anatomy, and clinical medicine and is a listed co-author on 135 national clinical trials publications in Retinal diseases. 

 

 

 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Knockdown of survivin results in inhibition of epithelial to mesenchymal transition in retinal pigment epithelial cells by attenuating the TGFβ pathway. Zhang P, Zhao G, Ji L, Yin J, Lu L, Li W, Zhou G, Chaum E, Yue J (2018) Biochem Biophys Res Commun 498(3): 573-578
    › Citation · 29522718 (PubMed) · PMC5920696 (PubMed Central)
  2. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E (2017) Invest Ophthalmol Vis Sci 58(4): 2366-2387
    › Primary publication · 28437526 (PubMed) · PMC5403116 (PubMed Central)
  3. Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells. Huo W, Zhao G, Yin J, Ouyang X, Wang Y, Yang C, Wang B, Dong P, Wang Z, Watari H, Chaum E, Pfeffer LM, Yue J (2017) J Cancer 8(1): 57-64
    › Primary publication · 28123598 (PubMed) · PMC5264040 (PubMed Central)
  4. Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis. Toutounchian JJ, Pagadala J, Miller DD, Baudry J, Park F, Chaum E, Yates CR (2017) Mol Pharmacol 91(1): 1-13
    › Primary publication · 27913654 (PubMed)
  5. Nasal Hemiretinal Vein Occlusion. Chaum E, Huddleston S, Mastellone J (2016) Ophthalmology 123(2): 399
    › Citation · 26802710 (PubMed)
  6. A Feedback Control Approach to Organic Drug Infusions Using Electrochemical Measurement. Myers MH, Li Y, Kivlehan F, Lindner E, Chaum E (2016) IEEE Trans Biomed Eng 63(3): 506-11
    › Citation · 26258937 (PubMed)
  7. Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium. Chaum E, Winborn CS, Bhattacharya S (2015) Mamm Genome 26(5-6): 210-21
    › Primary publication · 25963977 (PubMed) · PMC4450138 (PubMed Central)
  8. Propofol detection and quantification in human blood: the promise of feedback controlled, closed-loop anesthesia. Kivlehan F, Chaum E, Lindner E (2015) Analyst 140(1): 98-106
    › Primary publication · 25327876 (PubMed)
  9. Automated detection of microaneurysms using scale-adapted blob analysis and semi-supervised learning. Adal KM, Sidibé D, Ali S, Chaum E, Karnowski TP, Mériaudeau F (2014) Comput Methods Programs Biomed 114(1): 1-10
    › Citation · 24529636 (PubMed)
  10. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SSW, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP (2014) Neuron 81(3): 536-543
    › Primary publication · 24507191 (PubMed) · PMC3939050 (PubMed Central)
  11. Telemedicine and retinal imaging for improving diabetic retinopathy evaluation. Garg S, Jani PD, Kshirsagar AV, King B, Chaum E (2012) Arch Intern Med 172(21): 1677-8
    › Citation · 23026969 (PubMed)
  12. Statistical characterization and segmentation of drusen in fundus images. Santos-Villalobos H, Karnowski TP, Aykac D, Giancardo L, Li Y, Nichols T, Tobin KW, Chaum E (2011) Conf Proc IEEE Eng Med Biol Soc : 6236-41
    › Citation · 22255764 (PubMed)
  13. Exudate-based diabetic macular edema detection in fundus images using publicly available datasets. Giancardo L, Meriaudeau F, Karnowski TP, Li Y, Garg S, Tobin KW, Chaum E (2012) Med Image Anal 16(1): 216-26
    › Primary publication · 21865074 (PubMed)
  14. Molecular responses transduced by serial oxidative stress in the retinal pigment epithelium: feedback control modeling of gene expression. Chaum E, Yin J, Lang JC (2011) Neurochem Res 36(4): 574-82
    › Primary publication · 21181264 (PubMed)
  15. Correlation of intraocular pressure with intracranial pressure in children with severe head injuries. Spentzas T, Henricksen J, Patters AB, Chaum E (2010) Pediatr Crit Care Med 11(5): 593-8
    › Primary publication · 20081553 (PubMed)
  16. Quantitative AP-1 gene regulation by oxidative stress in the human retinal pigment epithelium. Chaum E, Yin J, Yang H, Thomas F, Lang JC (2009) J Cell Biochem 108(6): 1280-91
    › Primary publication · 19795388 (PubMed)
  17. Automated diagnosis of retinopathy by content-based image retrieval. Chaum E, Karnowski TP, Govindasamy VP, Abdelrahman M, Tobin KW (2008) Retina 28(10): 1463-77
    › Primary publication · 18997609 (PubMed)