Shu Xu
Last active: 4/14/2017

Shu Xu, Ph.D.

Official Affiliation: Biochemistry

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Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors. Uddin MJ, Crews BC, Xu S, Ghebreselasie K, Daniel CK, Kingsley PJ, Banerjee S, Marnett LJ (2016) ACS Chem Biol 11(11): 3052-3060
    › Primary publication · 27588346 (PubMed) · PMC5289892 (PubMed Central)
  2. Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression. Camarillo JM, Rose KL, Galligan JJ, Xu S, Marnett LJ (2016) Chem Res Toxicol 29(3): 323-32
    › Primary publication · 26910110 (PubMed) · PMC5058421 (PubMed Central)
  3. Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics. Konkle ME, Blobaum AL, Moth CW, Prusakiewicz JJ, Xu S, Ghebreselasie K, Akingbade D, Jacobs AT, Rouzer CA, Lybrand TP, Marnett LJ (2016) Biochemistry 55(2): 348-59
    › Primary publication · 26704937 (PubMed) · PMC4721528 (PubMed Central)
  4. nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2. Neumann W, Xu S, Sárosi MB, Scholz MS, Crews BC, Ghebreselasie K, Banerjee S, Marnett LJ, Hey-Hawkins E (2016) ChemMedChem 11(2): 175-8
    › Primary publication · 26088701 (PubMed) · PMC4900168 (PubMed Central)
  5. Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe. Uddin MJ, Crews BC, Ghebreselasie K, Daniel CK, Kingsley PJ, Xu S, Marnett LJ (2015) J Biomed Opt 20(5): 50502
    › Primary publication · 25970082 (PubMed) · PMC4430360 (PubMed Central)
  6. Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2. Blobaum AL, Xu S, Rowlinson SW, Duggan KC, Banerjee S, Kudalkar SN, Birmingham WR, Ghebreselasie K, Marnett LJ (2015) J Biol Chem 290(20): 12793-803
    › Primary publication · 25825493 (PubMed) · PMC4432295 (PubMed Central)
  7. 13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase. Kudalkar SN, Nikas SP, Kingsley PJ, Xu S, Galligan JJ, Rouzer CA, Banerjee S, Ji L, Eno MR, Makriyannis A, Marnett LJ (2015) J Biol Chem 290(12): 7897-909
    › Primary publication · 25648895 (PubMed) · PMC4367288 (PubMed Central)
  8. Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond. Xu S, Rouzer CA, Marnett LJ (2014) IUBMB Life 66(12): 803-11
    › Primary publication · 25537198 (PubMed) · PMC5300000 (PubMed Central)
  9. Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ (2014) J Biol Chem 289(10): 6799-6808
    › Primary publication · 24425867 (PubMed) · PMC3945341 (PubMed Central)
  10. Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib. Windsor MA, Valk PL, Xu S, Banerjee S, Marnett LJ (2013) Bioorg Med Chem Lett 23(21): 5860-4
    › Primary publication · 24060487 (PubMed) · PMC3857387 (PubMed Central)
  11. Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes. Windsor MA, Hermanson DJ, Kingsley PJ, Xu S, Crews BC, Ho W, Keenan CM, Banerjee S, Sharkey KA, Marnett LJ (2012) ACS Med Chem Lett 3(9): 759-763
    › Primary publication · 22984634 (PubMed) · PMC3441040 (PubMed Central)
  12. Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis. Xu S, Mueser TC, Marnett LJ, Funk MO (2012) Structure 20(9): 1490-7
    › Primary publication · 22795085 (PubMed) · PMC5226221 (PubMed Central)
  13. Complexes of the outer mitochondrial membrane protein mitoNEET with resveratrol-3-sulfate. Arif W, Xu S, Isailovic D, Geldenhuys WJ, Carroll RT, Funk MO (2011) Biochemistry 50(25): 5806-11
    › Primary publication · 21591687 (PubMed) · PMC5433850 (PubMed Central)
  14. EPR spectroscopy and electrospray ionization mass spectrometry reveal distinctive features of the iron site in leukocyte 12-lipoxygenase. Rapp J, Xu S, Sharp AM, Griffith WP, Kim YW, Funk MO (2009) Arch Biochem Biophys 490(1): 50-6
    › Primary publication · 19683507 (PubMed) · PMC2778285 (PubMed Central)
  15. Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. Xu S, Ge HM, Song YC, Shen Y, Ding H, Tan RX (2009) Chem Biodivers 6(5): 739-45
    › Primary publication · 19479839 (PubMed)
  16. Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Jiao RH, Xu S, Liu JY, Ge HM, Ding H, Xu C, Zhu HL, Tan RX (2006) Org Lett 8(25): 5709-12
    › Primary publication · 17134253 (PubMed)

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    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    Amino Acid Sequence Amino Acid Substitution Arachidonate 12-Lipoxygenase Ascomycota Calorimetry Colonic Neoplasms Computational Biology Cyclooxygenase 2 Dose-Response Relationship, Drug Escherichia coli Indomethacin Iron K562 Cells Mice, Nude Microscopy, Fluorescence Mitochondrial Proteins Models, Molecular Molecular Structure Oxygen Phenylpropionates Prostaglandin-Endoperoxide Synthases Prostaglandin-E Synthases Resveratrol Solubility Spectrometry, Mass, Electrospray Ionization Temperature Thermodynamics Transformation, Genetic Tumor Cells, Cultured Water