Eric Gamazon
Last active: 4/15/2017

Profile

At the intersection of functional genomics, complex traits genetics, and statistical genetics, my primary research interest is in developing and extending methods for elucidating the genetic architecture of complex disorders and pharmacologic phenotypes. An ongoing project involves understanding the effects of genome variation on gene regulation and utilizing information on expression quantitative trait loci (eQTLs) to expand on genetic association studies. I also work on integrating large-scale DNA biobank data and electronic medical records to enhance research in (and the translational utility of) genetics and genomics.

I am part of the GTEx Consortium and the T2D-GENES Consortium.  I was also a member of the International Warfarin Pharmacogenetics Consortium GWAS team.

 

Publications

Featured publications are shown below:

  1. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK, Teslovich TM, Blackwell TW, Bork-Jensen J, Burtt NP, Chen Y, Green T, Hartl C, Kang HM, Kumar A, Ladenvall C, Ma C, Moutsianas L, Pearson RD, Perry JR, Rayner NW, Robertson NR, Scott LJ, van de Bunt M, Eriksson JG, Jula A, Koskinen S, Lehtimäki T, Palotie A, Raitakari OT, Jacobs SB, Wessel J, Chu AY, Scott RA, Goodarzi MO, Blancher C, Buck G, Buck D, Chines PS, Gabriel S, Gjesing AP, Groves CJ, Hollensted M, Huyghe JR, Jackson AU, Jun G, Justesen JM, Mangino M, Murphy J, Neville M, Onofrio R, Small KS, Stringham HM, Trakalo J, Banks E, Carey J, Carneiro MO, DePristo M, Farjoun Y, Fennell T, Goldstein JI, Grant G, Hrabé de Angelis M, Maguire J, Neale BM, Poplin R, Purcell S, Schwarzmayr T, Shakir K, Smith JD, Strom TM, Wieland T, Lindstrom J, Brandslund I, Christensen C, Surdulescu GL, Lakka TA, Doney AS, Nilsson P, Wareham NJ, Langenberg C, Varga TV, Franks PW, Rolandsson O, Rosengren AH, Farook VS, Thameem F, Puppala S, Kumar S, Lehman DM, Jenkinson CP, Curran JE, Hale DE, Fowler SP, Arya R, DeFronzo RA, Abboud HE, Syvänen AC, Hicks PJ, Palmer ND, Ng MC, Bowden DW, Freedman BI, Esko T, Mägi R, Milani L, Mihailov E, Metspalu A, Narisu N, Kinnunen L, Bonnycastle LL, Swift A, Pasko D, Wood AR, Fadista J, Pollin TI, Barzilai N, Atzmon G, Glaser B, Thorand B, Strauch K, Peters A, Roden M, Müller-Nurasyid M, Liang L, Kriebel J, Illig T, Grallert H, Gieger C, Meisinger C, Lannfelt L, Musani SK, Griswold M, Taylor HA, Wilson G, Correa A, Oksa H, Scott WR, Afzal U, Tan ST, Loh M, Chambers JC, Sehmi J, Kooner JS, Lehne B, Cho YS, Lee JY, Han BG, Käräjämäki A, Qi Q, Qi L, Huang J, Hu FB, Melander O, Orho-Melander M, Below JE, Aguilar D, Wong TY, Liu J, Khor CC, Chia KS, Lim WY, Cheng CY, Chan E, Tai ES, Aung T, Linneberg A, Isomaa B, Meitinger T, Tuomi T, Hakaste L, Kravic J, Jørgensen ME, Lauritzen T, Deloukas P, Stirrups KE, Owen KR, Farmer AJ, Frayling TM, O'Rahilly SP, Walker M, Levy JC, Hodgkiss D, Hattersley AT, Kuulasmaa T, Stančáková A, Barroso I, Bharadwaj D, Chan J, Chandak GR, Daly MJ, Donnelly PJ, Ebrahim SB, Elliott P, Fingerlin T, Froguel P, Hu C, Jia W, Ma RC, McVean G, Park T, Prabhakaran D, Sandhu M, Scott J, Sladek R, Tandon N, Teo YY, Zeggini E, Watanabe RM, Koistinen HA, Kesaniemi YA, Uusitupa M, Spector TD, Salomaa V, Rauramaa R, Palmer CN, Prokopenko I, Morris AD, Bergman RN, Collins FS, Lind L, Ingelsson E, Tuomilehto J, Karpe F, Groop L, Jørgensen T, Hansen T, Pedersen O, Kuusisto J, Abecasis G, Bell GI, Blangero J, Cox NJ, Duggirala R, Seielstad M, Wilson JG, Dupuis J, Ripatti S, Hanis CL, Florez JC, Mohlke KL, Meigs JB, Laakso M, Morris AP, Boehnke M, Altshuler D, McCarthy MI, Gloyn AL, Lindgren CM (2017) Diabetes
    › Primary publication · 28341696 (PubMed)
  2. Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity. Wheeler HE, Gamazon ER, Frisina R, Perez-Cervantes C, El Charif O, Mapes B, Fossa SD, Feldman D, Hamilton R, Vaughn DJ, Beard C, Fung C, Kollmannsberger C, Kim J, Mushiroda T, Kubo M, Ardeshir-Rouhani-Fard S, Einhorn LH, Cox N, Dolan ME, Travis L (2016) Clin Cancer Res
    › Primary publication · 28039263 (PubMed)
  3. Consistency in large pharmacogenomic studies. Geeleher P, Gamazon ER, Seoighe C, Cox NJ, Huang RS (2016) Nature 540(7631): E1-E2
    › Primary publication · 27905415 (PubMed)
  4. The genetic architecture of type 2 diabetes. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Fernandez Tajes J, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SC, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MC, Palmer ND, Balkau B, Stancáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VK, Park KS, Saleheen D, So WY, Tam CH, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, van der Schouw YT, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney AS, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, Hrabé de Angelis M, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CN, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RC, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJ, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuler D, McCarthy MI (2016) Nature 536(7614): 41-7
    › Primary publication · 27398621 (PubMed) · PMC5034897 (PubMed Central)
  5. Imputing Gene Expression in Uncollected Tissues Within and Beyond GTEx. Wang J, Gamazon ER, Pierce BL, Stranger BE, Im HK, Gibbons RD, Cox NJ, Nicolae DL, Chen LS (2016) Am J Hum Genet 98(4): 697-708
    › Primary publication · 27040689 (PubMed) · PMC4833292 (PubMed Central)
  6. Novel genetic predictors of venous thromboembolism risk in African Americans. Hernandez W, Gamazon ER, Smithberger E, O'Brien TJ, Harralson AF, Tuck M, Barbour A, Kittles RA, Cavallari LH, Perera MA (2016) Blood 127(15): 1923-9
    › Primary publication · 26888256 (PubMed) · PMC4832509 (PubMed Central)
  7. A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology. Hungate EA, Vora SR, Gamazon ER, Moriyama T, Best T, Hulur I, Lee Y, Evans TJ, Ellinghaus E, Stanulla M, Rudant J, Orsi L, Clavel J, Milne E, Scott RJ, Pui CH, Cox NJ, Loh ML, Yang JJ, Skol AD, Onel K (2016) Nat Commun : 10635
    › Primary publication · 26868379 (PubMed) · PMC4754340 (PubMed Central)
  8. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE (2016) Pharmacogenomics J
    › Primary publication · 26856248 (PubMed) · PMC4980276 (PubMed Central)
  9. A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data. Kim YJ, Lee J, Kim BJ, T2D-Genes Consortium, Park T (2015) BMC Genomics : 1109
    › Primary publication · 26715385 (PubMed) · PMC4696174 (PubMed Central)
  10. A gene-based association method for mapping traits using reference transcriptome data. Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, GTEx Consortium, Nicolae DL, Cox NJ, Im HK (2015) Nat Genet 47(9): 1091-8
    › Primary publication · 26258848 (PubMed) · PMC4552594 (PubMed Central)
  11. Ethnic variation of TET2 SNP rs2454206 and association with clinical outcome in childhood AML: a report from the Children's Oncology Group. Kutny MA, Alonzo TA, Gamazon ER, Gerbing RB, Geraghty D, Lange B, Heerema NA, Sung L, Aplenc R, Franklin J, Raimondi SC, Hirsch BA, Konkashbaev A, Cox NJ, Onel K, Gamis AS, Meshinchi S (2015) Leukemia 29(12): 2424-6
    › Primary publication · 26126966 (PubMed) · PMC4675677 (PubMed Central)
  12. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. GTEx Consortium (2015) Science 348(6235): 648-60
    › Primary publication · 25954001 (PubMed) · PMC4547484 (PubMed Central)
  13. The impact of human copy number variation on gene expression. Gamazon ER, Stranger BE (2015) Brief Funct Genomics 14(5): 352-7
    › Primary publication · 25922366 (PubMed) · PMC4592354 (PubMed Central)
  14. SCAN database: facilitating integrative analyses of cytosine modification and expression QTL. Zhang W, Gamazon ER, Zhang X, Konkashbaev A, Liu C, Szilágyi KL, Dolan ME, Cox NJ (2015) Database (Oxford)
    › Primary publication · 25818895 (PubMed) · PMC4375357 (PubMed Central)
  15. Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait. Torres JM, Gamazon ER, Parra EJ, Below JE, Valladares-Salgado A, Wacher N, Cruz M, Hanis CL, Cox NJ (2014) Am J Hum Genet 95(5): 521-34
    › Primary publication · 25439722 (PubMed) · PMC4225593 (PubMed Central)
  16. Structural architecture of SNP effects on complex traits. Gamazon ER, Cox NJ, Davis LK (2014) Am J Hum Genet 95(5): 477-89
    › Primary publication · 25307299 (PubMed) · PMC4225594 (PubMed Central)
  17. Genome-wide interrogation of longitudinal FEV1 in children with asthma. Wu K, Gamazon ER, Im HK, Geeleher P, White SR, Solway J, Clemmer GL, Weiss ST, Tantisira KG, Cox NJ, Ratain MJ, Huang RS (2014) Am J Respir Crit Care Med 190(6): 619-27
    › Primary publication · 25221879 (PubMed) · PMC4214107 (PubMed Central)
  18. Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans. Daneshjou R, Gamazon ER, Burkley B, Cavallari LH, Johnson JA, Klein TE, Limdi N, Hillenmeyer S, Percha B, Karczewski KJ, Langaee T, Patel SR, Bustamante CD, Altman RB, Perera MA (2014) Blood 124(14): 2298-305
    › Primary publication · 25079360 (PubMed) · PMC4183989 (PubMed Central)
  19. Linking the genetic architecture of cytosine modifications with human complex traits. Zhang X, Moen EL, Liu C, Mu W, Gamazon ER, Delaney SM, Wing C, Godley LA, Dolan ME, Zhang W (2014) Hum Mol Genet 23(22): 5893-905
    › Primary publication · 24943591 (PubMed) · PMC4204771 (PubMed Central)
  20. Poly-omic prediction of complex traits: OmicKriging. Wheeler HE, Aquino-Michaels K, Gamazon ER, Trubetskoy VV, Dolan ME, Huang RS, Cox NJ, Im HK (2014) Genet Epidemiol 38(5): 402-15
    › Primary publication · 24799323 (PubMed) · PMC4072756 (PubMed Central)
  21. Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. Hart AB, Gamazon ER, Engelhardt BE, Sklar P, Kähler AK, Hultman CM, Sullivan PF, Neale BM, Faraone SV, Psychiatric Genomics Consortium: ADHD Subgroup, de Wit H, Cox NJ, Palmer AA (2014) Proc Natl Acad Sci U S A 111(16): 5968-73
    › Primary publication · 24711425 (PubMed) · PMC4000861 (PubMed Central)
  22. Obesity-associated variants within FTO form long-range functional connections with IRX3. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA (2014) Nature 507(7492): 371-5
    › Primary publication · 24646999 (PubMed) · PMC4113484 (PubMed Central)
  23. Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients. Pinto N, Gamazon ER, Antao N, Myers J, Stark AL, Konkashbaev A, Im HK, Diskin SJ, London WB, Ludeman SM, Maris JM, Cox NJ, Cohn SL, Dolan ME (2014) Clin Pharmacol Ther 95(6): 644-52
    › Primary publication · 24549002 (PubMed) · PMC4029857 (PubMed Central)
  24. Genomics of alternative splicing: evolution, development and pathophysiology. Gamazon ER, Stranger BE (2014) Hum Genet 133(6): 679-87
    › Primary publication · 24378600 (PubMed)
  25. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SM, Hounie AG, Illmann C, Jankovic J, Jenike MA, Kennedy JL, King RA, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, McCracken JT, McGrath LM, Mesa Restrepo SC, Moessner R, Morgan J, Muller H, Murphy DL, Naarden AL, Ochoa WC, Ophoff RA, Osiecki L, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner TJ, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosàrio MC, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Valencia Duarte AV, Vallada H, Van Nieuwerburgh F, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Westenberg HG, Shugart YY, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer NB, Pauls DL, Wray NR, Stewart SE, Mathews CA, Knowles JA, Cox NJ, Scharf JM (2013) PLoS Genet 9(10): e1003864
    › Primary publication · 24204291 (PubMed) · PMC3812053 (PubMed Central)
  26. Translating pharmacogenomics discoveries into the clinic: an implementation framework. Huang RS, Gamazon ER (2013) Genome Med 5(10): 94
    › Primary publication · 24134796 (PubMed) · PMC4066637 (PubMed Central)
  27. SCAN: a systems biology approach to pharmacogenomic discovery. Gamazon ER, Huang RS, Cox NJ (2013) Methods Mol Biol : 213-24
    › Primary publication · 23824859 (PubMed) · PMC4032625 (PubMed Central)
  28. Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis. Lertpiriyapong K, Whary MT, Muthupalani S, Lofgren JL, Gamazon ER, Feng Y, Ge Z, Wang TC, Fox JG (2014) Gut 63(1): 54-63
    › Primary publication · 23812323 (PubMed) · PMC4023484 (PubMed Central)
  29. Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AH, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA (2013) Lancet 382(9894): 790-6
    › Primary publication · 23755828 (PubMed) · PMC3759580 (PubMed Central)
  30. The Genotype-Tissue Expression (GTEx) project. GTEx Consortium (2013) Nat Genet 45(6): 580-5
    › Primary publication · 23715323 (PubMed) · PMC4010069 (PubMed Central)
  31. Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients. Gamazon ER, Lamba JK, Pounds S, Stark AL, Wheeler HE, Cao X, Im HK, Mitra AK, Rubnitz JE, Ribeiro RC, Raimondi S, Campana D, Crews KR, Wong SS, Welsh M, Hulur I, Gorsic L, Hartford CM, Zhang W, Cox NJ, Dolan ME (2013) Blood 121(21): 4366-76
    › Primary publication · 23538338 (PubMed) · PMC3663430 (PubMed Central)
  32. Trans-population analysis of genetic mechanisms of ethnic disparities in neuroblastoma survival. Gamazon ER, Pinto N, Konkashbaev A, Im HK, Diskin SJ, London WB, Maris JM, Dolan ME, Cox NJ, Cohn SL (2013) J Natl Cancer Inst 105(4): 302-9
    › Primary publication · 23243203 (PubMed) · PMC3691940 (PubMed Central)
  33. Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy. Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer EP, Hudis CA, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Cancer and Leukemia Group B, Cox NJ, Dolan ME (2013) Clin Cancer Res 19(2): 491-9
    › Primary publication · 23204130 (PubMed) · PMC3549006 (PubMed Central)
  34. Small science: high stakes. Gamazon ER (2012) Science 338(6109): 883
    › Primary publication · 23161975 (PubMed)
  35. An exponential combination procedure for set-based association tests in sequencing studies. Chen LS, Hsu L, Gamazon ER, Cox NJ, Nicolae DL (2012) Am J Hum Genet 91(6): 977-86
    › Primary publication · 23159251 (PubMed) · PMC3516612 (PubMed Central)
  36. Variants affecting exon skipping contribute to complex traits. Lee Y, Gamazon ER, Rebman E, Lee Y, Lee S, Dolan ME, Cox NJ, Lussier YA (2012) PLoS Genet 8(10): e1002998
    › Primary publication · 23133393 (PubMed) · PMC3486879 (PubMed Central)
  37. Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture? Elbein SC, Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ (2012) Am J Hum Genet 91(3): 466-77
    › Primary publication · 22958899 (PubMed) · PMC3512001 (PubMed Central)
  38. Genome-wide approaches in pharmacogenomics: heritability estimation and pharmacoethnicity as primary challenges. Gamazon ER, Perera M (2012) Pharmacogenomics 13(10): 1101-4
    › Primary publication · 22909197 (PubMed) · PMC3710727 (PubMed Central)
  39. Genome-wide association study of Tourette's syndrome. Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, North American Brain Expression Consortium, Hardy J, UK Human Brain Expression Database, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL (2013) Mol Psychiatry 18(6): 721-8
    › Primary publication · 22889924 (PubMed) · PMC3605224 (PubMed Central)
  40. Genome-wide association study of obsessive-compulsive disorder. Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH, Kennedy JL, Rosenberg D, Stein DJ, Hemmings SM, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy DL, Wendland JR, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg HG, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Conceição do Rosário M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A, North American Brain Expression Consortium, Hardy J, UK Brain Expression Database, Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL (2013) Mol Psychiatry 18(7): 788-98
    › Primary publication · 22889921 (PubMed) · PMC4218751 (PubMed Central)
  41. Identification of novel germline polymorphisms governing capecitabine sensitivity. O'Donnell PH, Stark AL, Gamazon ER, Wheeler HE, McIlwee BE, Gorsic L, Im HK, Huang RS, Cox NJ, Dolan ME (2012) Cancer 118(16): 4063-73
    › Primary publication · 22864933 (PubMed) · PMC3413892 (PubMed Central)
  42. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012) Proc Natl Acad Sci U S A 109(35): E2343-52
    › Primary publication · 22837397 (PubMed) · PMC3435171 (PubMed Central)
  43. Genetic architecture of microRNA expression: implications for the transcriptome and complex traits. Gamazon ER, Ziliak D, Im HK, LaCroix B, Park DS, Cox NJ, Huang RS (2012) Am J Hum Genet 90(6): 1046-63
    › Primary publication · 22658545 (PubMed) · PMC3370272 (PubMed Central)
  44. On sharing quantitative trait GWAS results in an era of multiple-omics data and the limits of genomic privacy. Im HK, Gamazon ER, Nicolae DL, Cox NJ (2012) Am J Hum Genet 90(4): 591-8
    › Primary publication · 22463877 (PubMed) · PMC3322234 (PubMed Central)
  45. Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer. Im HK, Gamazon ER, Stark AL, Huang RS, Cox NJ, Dolan ME (2012) PLoS Genet 8(2): e1002525
    › Primary publication · 22346769 (PubMed) · PMC3276560 (PubMed Central)
  46. Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry. Hou N, Zheng Y, Gamazon ER, Ogundiran TO, Adebamowo C, Nathanson KL, Domchek SM, Rebbeck TR, Simon MS, John EM, Hennis A, Nemesure B, Wu SY, Leske MC, Ambs S, Niu Q, Zhang J, Pierce B, Cox NJ, Olopade OI, Huo D (2012) Cancer Epidemiol Biomarkers Prev 21(3): 552-6
    › Primary publication · 22237986 (PubMed) · PMC3297695 (PubMed Central)
  47. Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Gamazon ER, Badner JA, Cheng L, Zhang C, Zhang D, Cox NJ, Gershon ES, Kelsoe JR, Greenwood TA, Nievergelt CM, Chen C, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI, Edenberg HJ, Foroud T, Koller DL, Scheftner WA, Coryell W, Rice J, Lawson WB, Nwulia EA, Hipolito M, Byerley W, McMahon FJ, Schulze TG, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Liu C (2013) Mol Psychiatry 18(3): 340-6
    › Primary publication · 22212596 (PubMed) · PMC3601550 (PubMed Central)
  48. Population differences in microRNA expression and biological implications. Huang RS, Gamazon ER, Ziliak D, Wen Y, Im HK, Zhang W, Wing C, Duan S, Bleibel WK, Cox NJ, Dolan ME (2011) RNA Biol 8(4): 692-701
    › Primary publication · 21691150 (PubMed) · PMC3225983 (PubMed Central)
  49. Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals. Below JE, Gamazon ER, Morrison JV, Konkashbaev A, Pluzhnikov A, McKeigue PM, Parra EJ, Elbein SC, Hallman DM, Nicolae DL, Bell GI, Cruz M, Cox NJ, Hanis CL (2011) Diabetologia 54(8): 2047-55
    › Primary publication · 21647700 (PubMed) · PMC3761075 (PubMed Central)
  50. Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. Innocenti F, Cooper GM, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, Ramirez J, Liu W, Lin YS, Moloney C, Aldred SF, Trinklein ND, Schuetz E, Nickerson DA, Thummel KE, Rieder MJ, Rettie AE, Ratain MJ, Cox NJ, Brown CD (2011) PLoS Genet 7(5): e1002078
    › Primary publication · 21637794 (PubMed) · PMC3102751 (PubMed Central)
  51. Copy number polymorphisms and anticancer pharmacogenomics. Gamazon ER, Huang RS, Dolan ME, Cox NJ (2011) Genome Biol 12(5): R46
    › Primary publication · 21609475 (PubMed) · PMC3219969 (PubMed Central)
  52. A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci. Gamazon ER, Nicolae DL, Cox NJ (2011) PLoS Genet 7(2): e1001292
    › Primary publication · 21304891 (PubMed) · PMC3033384 (PubMed Central)
  53. The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans. Perera MA, Gamazon E, Cavallari LH, Patel SR, Poindexter S, Kittles RA, Nicolae D, Cox NJ (2011) Clin Pharmacol Ther 89(3): 408-15
    › Primary publication · 21270790 (PubMed) · PMC3625373 (PubMed Central)
  54. Exprtarget: an integrative approach to predicting human microRNA targets. Gamazon ER, Im HK, Duan S, Lussier YA, Cox NJ, Dolan ME, Zhang W (2010) PLoS One 5(10): e13534
    › Primary publication · 20975837 (PubMed) · PMC2958831 (PubMed Central)
  55. Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci. Gamazon ER, Huang RS, Cox NJ, Dolan ME (2010) Proc Natl Acad Sci U S A 107(20): 9287-92
    › Primary publication · 20442332 (PubMed) · PMC2889115 (PubMed Central)
  56. Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ (2010) PLoS Genet 6(4): e1000888
    › Primary publication · 20369019 (PubMed) · PMC2848547 (PubMed Central)
  57. SCAN: SNP and copy number annotation. Gamazon ER, Zhang W, Konkashbaev A, Duan S, Kistner EO, Nicolae DL, Dolan ME, Cox NJ (2010) Bioinformatics 26(2): 259-62
    › Primary publication · 19933162 (PubMed) · PMC2852202 (PubMed Central)