Timothy Hohman
Last active: 4/10/2018

Profile

Dr. Timothy Hohman is an Assistant Professor of Neurology and a cognitive neuroscientist. He received his doctoral degree in neuroscience from American University focusing on cognitive and neural changes during normal aging. He also completed a fellowship as part of the National Institutes of Health Graduate Partnership Program in the Laboratory of Behavioral Neuroscience at the National Institute on Aging.  He completed his postdoctoral training at Vanderbilt University in the Center for Human Genetics Research where he applied neuroimaging and neuropsychological measures as quantitative endophenotypes in genetic analyses of Alzheimer’s disease. 

As a core faculty member of the Vanderbilt Memory & Alzheimer's Center, Dr. Hohman’s research leverages advanced computational approaches from genomics, proteomics, and neuroscience to identify novel markers of Alzheimer’s disease risk and resilience. His interdisciplinary collaborations with the Alzheimer’s Disease Genetics Consortium and others seek to develop new directions in AD research by emphasizing the biology of resilience and highlighting complex genotype-phenotype interactions.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Subclinical Compromise in Cardiac Strain Relates to Lower Cognitive Performances in Older Adults. Kresge HA, Khan OA, Wagener MA, Liu D, Terry JG, Nair S, Cambronero FE, Gifford KA, Osborn KE, Hohman TJ, Pechman KR, Bell SP, Wang TJ, Carr JJ, Jefferson AL (2018) J Am Heart Assoc 7(4)
    › Primary publication · 29440034 (PubMed) · PMC5850190 (PubMed Central)
  2. Assessing Working Memory in Mild Cognitive Impairment with Serial Order Recall. Emrani S, Libon DJ, Lamar M, Price CC, Jefferson AL, Gifford KA, Hohman TJ, Nation DA, Delano-Wood L, Jak A, Bangen KJ, Bondi MW, Brickman AM, Manly J, Swenson R, Au R, Consortium for Clinical and Epidemiological Neuropsychological Data Analysis (CENDA) (2018) J Alzheimers Dis 61(3): 917-928
    › Primary publication · 29254087 (PubMed) · PMC5901759 (PubMed Central)
  3. APOE allele frequencies in suspected non-amyloid pathophysiology (SNAP) and the prodromal stages of Alzheimer's Disease. Hohman TJ, Dumitrescu L, Oksol A, Wagener M, Gifford KA, Jefferson AL, Alzheimer’s Disease Neuroimaging Initiative (2017) PLoS One 12(11): e0188501
    › Primary publication · 29190651 (PubMed) · PMC5708777 (PubMed Central)
  4. Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E ε4 and the Risk of Cognitive Decline and Incident Dementia. Bell SP, Liu D, Samuels LR, Shah AS, Gifford KA, Hohman TJ, Jefferson AL (2017) J Nutr Health Aging 21(10): 1259-1267
    › Primary publication · 29188888 (PubMed) · PMC5736008 (PubMed Central)
  5. Lower cardiac index levels relate to lower cerebral blood flow in older adults. Jefferson AL, Liu D, Gupta DK, Pechman KR, Watchmaker JM, Gordon EA, Rane S, Bell SP, Mendes LA, Davis LT, Gifford KA, Hohman TJ, Wang TJ, Donahue MJ (2017) Neurology 89(23): 2327-2334
    › Primary publication · 29117962 (PubMed) · PMC5719926 (PubMed Central)
  6. Evaluating Alzheimer's disease biomarkers as mediators of age-related cognitive decline. Hohman TJ, Tommet D, Marks S, Contreras J, Jones R, Mungas D, Alzheimer's Neuroimaging Initiative (2017) Neurobiol Aging : 120-128
    › Primary publication · 28732249 (PubMed) · PMC5710827 (PubMed Central)
  7. Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M (2017) Mol Psychiatry 22(1): 13-23
    › Primary publication · 27872486 (PubMed) · PMC5726508 (PubMed Central)
  8. Asymptomatic Alzheimer disease: Defining resilience. Hohman TJ, McLaren DG, Mormino EC, Gifford KA, Libon DJ, Jefferson AL, Alzheimer's Disease Neuroimaging Initiative (2016) Neurology 87(23): 2443-2450
    › Primary publication · 27815399 (PubMed) · PMC5177674 (PubMed Central)
  9. Genetic resilience to amyloid related cognitive decline. Hohman TJ, Dumitrescu L, Cox NJ, Jefferson AL, Alzheimer’s Neuroimaging Initiative (2017) Brain Imaging Behav 11(2): 401-409
    › Primary publication · 27743375 (PubMed) · PMC5392179 (PubMed Central)
  10. Brain network changes and memory decline in aging. Beason-Held LL, Hohman TJ, Venkatraman V, An Y, Resnick SM (2017) Brain Imaging Behav 11(3): 859-873
    › Primary publication · 27319002 (PubMed) · PMC5164979 (PubMed Central)
  11. The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview. Jefferson AL, Gifford KA, Acosta LM, Bell SP, Donahue MJ, Davis LT, Gottlieb J, Gupta DK, Hohman TJ, Lane EM, Libon DJ, Mendes LA, Niswender K, Pechman KR, Rane S, Ruberg FL, Su YR, Zetterberg H, Liu D (2016) J Alzheimers Dis 52(2): 539-59
    › Primary publication · 26967211 (PubMed) · PMC4866875 (PubMed Central)
  12. Sex differences in the association between AD biomarkers and cognitive decline. Koran MEI, Wagener M, Hohman TJ, Alzheimer’s Neuroimaging Initiative (2017) Brain Imaging Behav 11(1): 205-213
    › Primary publication · 26843008 (PubMed) · PMC4972701 (PubMed Central)
  13. Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, Alzheimer's Disease Genetics Consortium (2016) Neurobiol Aging : 141-150
    › Primary publication · 26827652 (PubMed) · PMC4735733 (PubMed Central)
  14. A Mutual Self- and Informant-Report of Cognitive Complaint Correlates with Neuropathological Outcomes in Mild Cognitive Impairment. Gifford KA, Liu D, Hohman TJ, Xu M, Han X, Romano RR, Fritzsche LR, Abel T, Jefferson AL (2015) PLoS One 10(11): e0141831
    › Primary publication · 26539829 (PubMed) · PMC4634952 (PubMed Central)
  15. Associations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum. Gifford KA, Phillips JS, Samuels LR, Lane EM, Bell SP, Liu D, Hohman TJ, Romano RR, Fritzsche LR, Lu Z, Jefferson AL, Alzheimer’s Disease Neuroimaging Initiative (2015) J Int Neuropsychol Soc 21(6): 455-67
    › Primary publication · 26219209 (PubMed) · PMC4657447 (PubMed Central)
  16. GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension. Hohman TJ, Chibnik L, Bush WS, Jefferson AL, De Jaeger PL, Thornton-Wells TA, Bennett DA, Schneider JA (2015) Neurotox Res 28(3): 232-8
    › Primary publication · 26194614 (PubMed) · PMC4625986 (PubMed Central)
  17. Stroke risk interacts with Alzheimer's disease biomarkers on brain aging outcomes. Hohman TJ, Samuels LR, Liu D, Gifford KA, Mukherjee S, Benson EM, Abel T, Ruberg FL, Jefferson AL, Alzheimer's Neuroimaging Initiative (2015) Neurobiol Aging 36(9): 2501-8
    › Primary publication · 26119224 (PubMed) · PMC4523400 (PubMed Central)
  18. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM, Lang R, Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA, Alzheimer Disease Genetics Consortium (2016) Alzheimers Dement 12(3): 233-43
    › Primary publication · 26092349 (PubMed) · PMC4681680 (PubMed Central)
  19. The role of vascular endothelial growth factor in neurodegeneration and cognitive decline: exploring interactions with biomarkers of Alzheimer disease. Hohman TJ, Bell SP, Jefferson AL, Alzheimer’s Disease Neuroimaging Initiative (2015) JAMA Neurol 72(5): 520-9
    › Primary publication · 25751166 (PubMed) · PMC4428948 (PubMed Central)
  20. Resting-State Functional Connectivity in Individuals with Down Syndrome and Williams Syndrome Compared with Typically Developing Controls. Vega JN, Hohman TJ, Pryweller JR, Dykens EM, Thornton-Wells TA (2015) Brain Connect 5(8): 461-75
    › Primary publication · 25712025 (PubMed) · PMC4601631 (PubMed Central)
  21. Adverse vascular risk is related to cognitive decline in older adults. Jefferson AL, Hohman TJ, Liu D, Haj-Hassan S, Gifford KA, Benson EM, Skinner JS, Lu Z, Sparling J, Sumner EC, Bell S, Ruberg FL (2015) J Alzheimers Dis 44(4): 1361-73
    › Primary publication · 25471188 (PubMed) · PMC4336578 (PubMed Central)
  22. Genetic variation modifies risk for neurodegeneration based on biomarker status. Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Neuroimaging Initiative (2014) Front Aging Neurosci : 183
    › Primary publication · 25140149 (PubMed) · PMC4121544 (PubMed Central)
  23. Differences in age-related effects on brain volume in Down syndrome as compared to Williams syndrome and typical development. Koran ME, Hohman TJ, Edwards CM, Vega JN, Pryweller JR, Slosky LE, Crockett G, Villa de Rey L, Meda SA, Dankner N, Avery SN, Blackford JU, Dykens EM, Thornton-Wells TA (2014) J Neurodev Disord 6(1): 8
    › Primary publication · 24713364 (PubMed) · PMC4022321 (PubMed Central)
  24. Genetic modification of the relationship between phosphorylated tau and neurodegeneration. Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Disease Neuroimaging Initiative (2014) Alzheimers Dement 10(6): 637-645.e1
    › Primary publication · 24656848 (PubMed) · PMC4169762 (PubMed Central)
  25. Epistatic genetic effects among Alzheimer's candidate genes. Hohman TJ, Koran ME, Thornton-Wells T, Alzheimer's Neuroimaging Initiative (2013) PLoS One 8(11): e80839
    › Primary publication · 24260488 (PubMed) · PMC3832488 (PubMed Central)
  26. Interactions between GSK3β and amyloid genes explain variance in amyloid burden. Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Neuroimaging Initiative (2014) Neurobiol Aging 35(3): 460-5
    › Primary publication · 24112793 (PubMed) · PMC3864626 (PubMed Central)
  27. Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size. Koran ME, Hohman TJ, Meda SA, Thornton-Wells TA (2014) J Alzheimers Dis 38(1): 145-54
    › Primary publication · 24077433 (PubMed) · PMC3815519 (PubMed Central)
  28. Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography. Koran ME, Hohman TJ, Thornton-Wells TA (2014) Hum Genet 133(1): 85-93
    › Primary publication · 24026422 (PubMed) · PMC4045094 (PubMed Central)
  29. Flexibility of event boundaries in autobiographical memory. Hohman TJ, Peynircioğlu ZF, Beason-Held LL (2013) Memory 21(2): 249-60
    › Primary publication · 22989194 (PubMed) · PMC3914309 (PubMed Central)
  30. Cognitive complaints, depressive symptoms, and cognitive impairment: are they related? Hohman TJ, Beason-Held LL, Resnick SM (2011) J Am Geriatr Soc 59(10): 1908-12
    › Primary publication · 22091504 (PubMed) · PMC3227017 (PubMed Central)
  31. Subjective cognitive complaints and longitudinal changes in memory and brain function. Hohman TJ, Beason-Held LL, Lamar M, Resnick SM (2011) Neuropsychology 25(1): 125-30
    › Primary publication · 20919769 (PubMed) · PMC3103103 (PubMed Central)
  32. Revelation effect in metamemory. Young KD, Peynircioğlu ZF, Hohman TJ (2009) Psychon Bull Rev 16(5): 952-6
    › Primary publication · 19815804 (PubMed)