C. Henrique Serezani
Last active: 11/2/2017

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Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection. Salina AC, Souza TP, Serezani CH, Medeiros AI (2017) Innate Immun 23(3): 219-227
    › Primary publication · 28359217 (PubMed)
  2. Imbalance between HDAC and HAT activities drives aberrant STAT1/MyD88 expression in macrophages from type 1 diabetic mice. Filgueiras LR, Brandt SL, Ramalho TR, Jancar S, Serezani CH (2017) J Diabetes Complications 31(2): 334-339
    › Primary publication · 27623388 (PubMed) · PMC5296405 (PubMed Central)
  3. Topical Prostaglandin E Analog Restores Defective Dendritic Cell-Mediated Th17 Host Defense Against Methicillin-Resistant Staphylococcus Aureus in the Skin of Diabetic Mice. Dejani NN, Brandt SL, Piñeros A, Glosson-Byers NL, Wang S, Son YM, Medeiros AI, Serezani CH (2016) Diabetes 65(12): 3718-3729
    › Primary publication · 27605625 (PubMed) · PMC5127243 (PubMed Central)
  4. PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages. Ishizuka EK, Filgueiras LR, Rios FJ, Serezani CH, Jancar S (2016) Sci Rep : 32092
    › Primary publication · 27554194 (PubMed) · PMC4995467 (PubMed Central)
  5. Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88. Zhang H, Rodriguez S, Wang L, Wang S, Serezani H, Kapur R, Cardoso AA, Carlesso N (2016) Stem Cell Reports 6(6): 940-956
    › Primary publication · 27264973 (PubMed) · PMC4911503 (PubMed Central)
  6. Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation. Li XJ, Deng L, Brandt SL, Goodwin CB, Ma P, Yang Z, Mali RS, Liu Z, Kapur R, Serezani CH, Chan RJ (2016) Oncotarget 7(17): 23096-105
    › Primary publication · 27049833 (PubMed) · PMC5029613 (PubMed Central)
  7. Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. Zoccal KF, Sorgi CA, Hori JI, Paula-Silva FW, Arantes EC, Serezani CH, Zamboni DS, Faccioli LH (2016) Nat Commun : 10760
    › Primary publication · 26907476 (PubMed) · PMC4766425 (PubMed Central)
  8. Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis. Ribeiro LR, Loures FV, de Araújo EF, Feriotti C, Costa TA, Serezani CH, Jancar S, Calich VL (2015) Mediators Inflamm : 852574
    › Primary publication · 26635449 (PubMed) · PMC4618125 (PubMed Central)
  9. Leukotriene B4 as a Potential Therapeutic Target for the Treatment of Metabolic Disorders. Filgueiras LR, Serezani CH, Jancar S (2015) Front Immunol : 515
    › Primary publication · 26500652 (PubMed) · PMC4597104 (PubMed Central)
  10. Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages. Carrasco SE, Troxell B, Yang Y, Brandt SL, Li H, Sandusky GE, Condon KW, Serezani CH, Yang XF (2015) Infect Immun 83(12): 4848-60
    › Primary publication · 26438793 (PubMed) · PMC4645385 (PubMed Central)
  11. MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation. Wang Z, Brandt S, Medeiros A, Wang S, Wu H, Dent A, Serezani CH (2015) PLoS One 10(2): e0115855
    › Primary publication · 25706647 (PubMed) · PMC4338261 (PubMed Central)
  12. Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes. Filgueiras LR, Brandt SL, Wang S, Wang Z, Morris DL, Evans-Molina C, Mirmira RG, Jancar S, Serezani CH (2015) Sci Signal 8(361): ra10
    › Primary publication · 25628460 (PubMed) · PMC4356178 (PubMed Central)
  13. Essential role of leukotriene B4 on Leishmania (Viannia) braziliensis killing by human macrophages. Morato CI, da Silva IA, Borges AF, Dorta ML, Oliveira MA, Jancar S, Serezani CH, Ribeiro-Dias F (2014) Microbes Infect 16(11): 945-53
    › Primary publication · 25195516 (PubMed)
  14. Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages. da Silva-Souza HA, Lira MN, Costa-Junior HM, da Cruz CM, Vasconcellos JS, Mendes AN, Pimenta-Reis G, Alvarez CL, Faccioli LH, Serezani CH, Schachter J, Persechini PM (2014) Biochim Biophys Acta 1838(7): 1967-77
    › Primary publication · 24743022 (PubMed)
  15. PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis. Ferreira AE, Sisti F, Sônego F, Wang S, Filgueiras LR, Brandt S, Serezani AP, Du H, Cunha FQ, Alves-Filho JC, Serezani CH (2014) J Immunol 192(5): 2357-65
    › Primary publication · 24489087 (PubMed) · PMC3943997 (PubMed Central)
  16. Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation. Wang Z, Filgueiras LR, Wang S, Serezani AP, Peters-Golden M, Jancar S, Serezani CH (2014) J Immunol 192(5): 2349-56
    › Primary publication · 24477912 (PubMed) · PMC3943984 (PubMed Central)
  17. The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis. Secatto A, Soares EM, Locachevic GA, Assis PA, Paula-Silva FW, Serezani CH, de Medeiros AI, Faccioli LH (2014) PLoS One 9(1): e85083
    › Primary publication · 24465479 (PubMed) · PMC3897419 (PubMed Central)
  18. EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii. Rogers LM, Thelen T, Fordyce K, Bourdonnay E, Lewis C, Yu H, Zhang J, Xie J, Serezani CH, Peters-Golden M, Aronoff DM (2014) Am J Reprod Immunol 71(1): 34-43
    › Primary publication · 23902376 (PubMed) · PMC3864121 (PubMed Central)
  19. Proinflammatory responses of heme in alveolar macrophages: repercussion in lung hemorrhagic episodes. Simões RL, Arruda MA, Canetti C, Serezani CH, Fierro IM, Barja-Fidalgo C (2013) Mediators Inflamm : 946878
    › Primary publication · 23690673 (PubMed) · PMC3652176 (PubMed Central)
  20. Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant. Domingo-Gonzalez R, Katz S, Serezani CH, Moore TA, Levine AM, Moore BB (2013) J Immunol 190(11): 5809-17
    › Primary publication · 23630358 (PubMed) · PMC3660503 (PubMed Central)
  21. Differential stem- and progenitor-cell trafficking by prostaglandin E2. Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise TA, Srour EF, Pelus LM (2013) Nature 495(7441): 365-9
    › Primary publication · 23485965 (PubMed) · PMC3606692 (PubMed Central)
  22. Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes. Soares EM, Mason KL, Rogers LM, Serezani CH, Faccioli LH, Aronoff DM (2013) J Immunol 190(4): 1614-22
    › Primary publication · 23325886 (PubMed) · PMC3563855 (PubMed Central)
  23. Murine colitis is mediated by vimentin. Mor-Vaknin N, Legendre M, Yu Y, Serezani CH, Garg SK, Jatzek A, Swanson MD, Gonzalez-Hernandez MJ, Teitz-Tennenbaum S, Punturieri A, Engleberg NC, Banerjee R, Peters-Golden M, Kao JY, Markovitz DM (2013) Sci Rep : 1045
    › Primary publication · 23304436 (PubMed) · PMC3540396 (PubMed Central)
  24. Sepsis-induced acute lung injury (ALI) is milder in diabetic rats and correlates with impaired NFkB activation. Filgueiras LR, Martins JO, Serezani CH, Capelozzi VL, Montes MB, Jancar S (2012) PLoS One 7(9): e44987
    › Primary publication · 23024779 (PubMed) · PMC3443211 (PubMed Central)
  25. Prostaglandin E2 and the suppression of phagocyte innate immune responses in different organs. Medeiros A, Peres-Buzalaf C, Fortino Verdan F, Serezani CH (2012) Mediators Inflamm : 327568
    › Primary publication · 23024463 (PubMed) · PMC3449139 (PubMed Central)
  26. Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. Serezani CH, Kane S, Collins L, Morato-Marques M, Osterholzer JJ, Peters-Golden M (2012) J Immunol 189(2): 906-15
    › Primary publication · 22696442 (PubMed) · PMC3392366 (PubMed Central)
  27. Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia. Mancuso P, Myers MG, Goel D, Serezani CH, O'Brien E, Goldberg J, Aronoff DM, Peters-Golden M (2012) J Immunol 189(2): 867-75
    › Primary publication · 22685316 (PubMed) · PMC3392451 (PubMed Central)
  28. Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2. Bourdonnay E, Serezani CH, Aronoff DM, Peters-Golden M (2012) J Leukoc Biol 92(1): 219-31
    › Primary publication · 22544939 (PubMed) · PMC3382311 (PubMed Central)
  29. 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection. Secatto A, Rodrigues LC, Serezani CH, Ramos SG, Dias-Baruffi M, Faccioli LH, Medeiros AI (2012) PLoS One 7(3): e31701
    › Primary publication · 22448213 (PubMed) · PMC3308949 (PubMed Central)
  30. PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi. Serezani CH, Kane S, Medeiros AI, Cornett AM, Kim SH, Marques MM, Lee SP, Lewis C, Bourdonnay E, Ballinger MN, White ES, Peters-Golden M (2012) Sci Signal 5(210): ra12
    › Primary publication · 22317922 (PubMed) · PMC3400468 (PubMed Central)
  31. Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling. Zaslona Z, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M (2012) Blood 119(10): 2358-67
    › Primary publication · 22234697 (PubMed) · PMC3311259 (PubMed Central)
  32. Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity. Morato-Marques M, Campos MR, Kane S, Rangel AP, Lewis C, Ballinger MN, Kim SH, Peters-Golden M, Jancar S, Serezani CH (2011) J Biol Chem 286(33): 28902-13
    › Primary publication · 21715328 (PubMed) · PMC3190697 (PubMed Central)
  33. Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages. Kim SH, Serezani CH, Okunishi K, Zaslona Z, Aronoff DM, Peters-Golden M (2011) J Biol Chem 286(11): 8875-83
    › Primary publication · 21247892 (PubMed) · PMC3058957 (PubMed Central)
  34. Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. Serezani CH, Lewis C, Jancar S, Peters-Golden M (2011) J Clin Invest 121(2): 671-82
    › Primary publication · 21206089 (PubMed) · PMC3026722 (PubMed Central)
  35. The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages. Thelen T, Hao Y, Medeiros AI, Curtis JL, Serezani CH, Kobzik L, Harris LH, Aronoff DM (2010) J Immunol 185(7): 4328-35
    › Primary publication · 20810988 (PubMed)
  36. Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia. Mancuso P, Lewis C, Serezani CH, Goel D, Peters-Golden M (2010) Infect Immun 78(5): 2264-71
    › Primary publication · 20231413 (PubMed) · PMC2863513 (PubMed Central)
  37. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Serezani CH, Aronoff DM, Sitrin RG, Peters-Golden M (2009) Blood 114(15): 3316-24
    › Primary publication · 19657115 (PubMed) · PMC2759654 (PubMed Central)
  38. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P (2009) J Immunol 183(4): 2642-9
    › Primary publication · 19635910 (PubMed) · PMC4016992 (PubMed Central)
  39. Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. Campos MR, Serezani CH, Peters-Golden M, Jancar S (2009) Mol Immunol 46(6): 1204-11
    › Primary publication · 19223078 (PubMed)
  40. Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. Medeiros AI, Serezani CH, Lee SP, Peters-Golden M (2009) J Exp Med 206(1): 61-8
    › Primary publication · 19124657 (PubMed) · PMC2626688 (PubMed Central)
  41. Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. Lee SP, Serezani CH, Medeiros AI, Ballinger MN, Peters-Golden M (2009) J Immunol 182(1): 530-7
    › Primary publication · 19109185 (PubMed)
  42. Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. Medeiros AI, Sá-Nunes A, Turato WM, Secatto A, Frantz FG, Sorgi CA, Serezani CH, Deepe GS, Faccioli LH (2008) J Immunol 181(12): 8544-51
    › Primary publication · 19050273 (PubMed)
  43. ATP-induced apoptosis involves a Ca2+-independent phospholipase A2 and 5-lipoxygenase in macrophages. Costa-Junior HM, Mendes AN, Davis GH, da Cruz CM, Ventura AL, Serezani CH, Faccioli LH, Nomizo A, Freire-de-Lima CG, Bisaggio Rda C, Persechini PM (2009) Prostaglandins Other Lipid Mediat 88(1-2): 51-61
    › Primary publication · 18984060 (PubMed)
  44. Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. Chung J, Serezani CH, Huang SK, Stern JN, Keskin DB, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M (2008) J Immunol 181(8): 5501-9
    › Primary publication · 18832707 (PubMed) · PMC3077557 (PubMed Central)
  45. TLR4/MYD88-dependent, LPS-induced synthesis of PGE2 by macrophages or dendritic cells prevents anti-CD3-mediated CD95L upregulation in T cells. Weinlich R, Bortoluci KR, Chehab CF, Serezani CH, Ulbrich AG, Peters-Golden M, Russo M, Amarante-Mendes GP (2008) Cell Death Differ 15(12): 1901-9
    › Primary publication · 18820644 (PubMed)
  46. Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii. Aronoff DM, Hao Y, Chung J, Coleman N, Lewis C, Peres CM, Serezani CH, Chen GH, Flamand N, Brock TG, Peters-Golden M (2008) J Immunol 180(12): 8222-30
    › Primary publication · 18523288 (PubMed) · PMC2667109 (PubMed Central)
  47. Cyclic AMP: master regulator of innate immune cell function. Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M (2008) Am J Respir Cell Mol Biol 39(2): 127-32
    › Primary publication · 18323530 (PubMed) · PMC2720142 (PubMed Central)
  48. Stimulatory Effects of Peroxisome Proliferator-Activated Receptor-gamma on Fcgamma Receptor-Mediated Phagocytosis by Alveolar Macrophages. Aronoff DM, Serezani CH, Carstens JK, Marshall T, Gangireddy SR, Peters-Golden M, Reddy RC (2007) PPAR Res : 52546
    › Primary publication · 18253476 (PubMed) · PMC2220046 (PubMed Central)
  49. Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages. Canetti C, Serezani CH, Atrasz RG, White ES, Aronoff DM, Peters-Golden M (2007) J Immunol 179(12): 8350-6
    › Primary publication · 18056380 (PubMed)
  50. Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcgamma-receptor-mediated phagocytosis in alveolar macrophages. Brock TG, Serezani CH, Carstens JK, Peters-Golden M, Aronoff DM (2008) Exp Cell Res 314(2): 255-63
    › Primary publication · 18021770 (PubMed) · PMC2390918 (PubMed Central)
  51. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. Peres CM, Aronoff DM, Serezani CH, Flamand N, Faccioli LH, Peters-Golden M (2007) J Immunol 179(8): 5454-61
    › Primary publication · 17911632 (PubMed)
  52. NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis. Coffey MJ, Serezani CH, Phare SM, Flamand N, Peters-Golden M (2007) J Leukoc Biol 82(6): 1585-91
    › Primary publication · 17761955 (PubMed)
  53. Leukotrienes: mediators that have been typecast as villains. Flamand N, Mancuso P, Serezani CH, Brock TG (2007) Cell Mol Life Sci 64(19-20): 2657-70
    › Primary publication · 17639273 (PubMed)
  54. Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase. Serezani CH, Chung J, Ballinger MN, Moore BB, Aronoff DM, Peters-Golden M (2007) Am J Respir Cell Mol Biol 37(5): 562-70
    › Primary publication · 17585108 (PubMed) · PMC2048683 (PubMed Central)
  55. Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities. Aronoff DM, Peres CM, Serezani CH, Ballinger MN, Carstens JK, Coleman N, Moore BB, Peebles RS, Faccioli LH, Peters-Golden M (2007) J Immunol 178(3): 1628-34
    › Primary publication · 17237412 (PubMed)
  56. Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility. Serezani CH, Perrela JH, Russo M, Peters-Golden M, Jancar S (2006) J Immunol 177(5): 3201-8
    › Primary publication · 16920959 (PubMed)
  57. Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa. Ballinger MN, Paine R, Serezani CH, Aronoff DM, Choi ES, Standiford TJ, Toews GB, Moore BB (2006) Am J Respir Cell Mol Biol 34(6): 766-74
    › Primary publication · 16474098 (PubMed) · PMC2644237 (PubMed Central)
  58. Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. Serezani CH, Aronoff DM, Jancar S, Peters-Golden M (2005) J Leukoc Biol 78(4): 976-84
    › Primary publication · 16006535 (PubMed)
  59. Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M (2005) Blood 106(3): 1067-75
    › Primary publication · 15718414 (PubMed) · PMC1895163 (PubMed Central)
  60. Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1. Aronoff DM, Canetti C, Serezani CH, Luo M, Peters-Golden M (2005) J Immunol 174(2): 595-9
    › Primary publication · 15634874 (PubMed)
  61. Evaluation of the murine immune response to Leishmania meta 1 antigen delivered as recombinant protein or DNA vaccine. Serezani CH, Franco AR, Wajc M, Umada Yokoyama-Yasunaka JK, Wunderlich G, Borges MM, Uliana SR (2002) Vaccine 20(31-32): 3755-63
    › Primary publication · 12399206 (PubMed)