Functional gastrointestinal and motility disorders are the most common digestive diseases. In the United States, nearly one of every four people are affected by these disorders. Unfortunately, in cases of gut stasis or improper innervation, such as Hirschprung’s disease, the most reliable treatment at this time involves resecting the diseased portions of the gut. The recovery process from such procedures can be quite challenging for many patients; in the U.S. alone, over 130,000 ostomy surgeries are performed each year!
Because the enteric nervous system is the key regulator of gut homeostasis and motility, the goal of my research is to identify novel therapeutic targets within human enteric nerves that can be used to treat these diseases and fully restore gut function. Such discoveries will be integral in designing new pharmaceutical treatments and stem cell therapies.
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Key: MeSH Term KeywordAnimals Body Composition Brain Cerebrospinal Fluid Eating enteric nervous system Feeding Behavior Female Ganglia Gastrointestinal Diseases Gastrointestinal Hormones Glucose Transporter Type 1 Hypoglycemic Agents Insulin Insulin, Isophane Insulin, Long-Acting Insulin Resistance In Vitro Techniques Laser Capture Microdissection Male Mice, Inbred C57BL Microvessels Neuroscience nutrition Obesity obesity Ovariectomy Peptides Protein Transport Rats, Long-Evans Rats, Wistar RNA Satiation Sincalide Synaptophysin