Chris Smith
Last active: 5/14/2018


I am interested in understanding the neural mechanisms of choice behavior and other executive processes. Using behavioral genetic and neuroimaging techniques, I hope to better understand how choice preferences are encoded in the brain and the role of neural modulators in shaping these processes. Understanding choice behavior and how it can go awry has implications for why individuals make irrational choices in their daily lives and the poor choices seen in psychopathologies like drug addiction.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. [F]fallypride characterization of striatal and extrastriatal D receptors in Parkinson's disease. Stark AJ, Smith CT, Petersen KJ, Trujillo P, van Wouwe NC, Donahue MJ, Kessler RM, Deutch AY, Zald DH, Claassen DO (2018) Neuroimage Clin : 433-442
    › Primary publication · 29541577 (PubMed) · PMC5849871 (PubMed Central)
  2. Nigrostriatal and Mesolimbic D Receptor Expression in Parkinson's Disease Patients with Compulsive Reward-Driven Behaviors. Stark AJ, Smith CT, Lin YC, Petersen KJ, Trujillo P, van Wouwe NC, Kang H, Donahue MJ, Kessler RM, Zald DH, Claassen DO (2018) J Neurosci 38(13): 3230-3239
    › Primary publication · 29483278 (PubMed) · PMC5884458 (PubMed Central)
  3. COMT ValMet Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function. Elton A, Smith CT, Parrish MH, Boettiger CA (2017) Front Hum Neurosci : 578
    › Primary publication · 29270116 (PubMed) · PMC5723646 (PubMed Central)
  4. FTO affects food cravings and interacts with age to influence age-related decline in food cravings. Dang LC, Samanez-Larkin GR, Smith CT, Castrellon JJ, Perkins SF, Cowan RL, Claassen DO, Zald DH (2018) Physiol Behav : 188-193
    › Primary publication · 29233619 (PubMed) · PMC5994171 (PubMed Central)
  5. Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences. Smith CT, Crawford JL, Dang LC, Seaman KL, San Juan MD, Vijay A, Katz DT, Matuskey D, Cowan RL, Morris ED, Zald DH, Samanez-Larkin GR (2019) J Cereb Blood Flow Metab 39(5): 822-833
    › Primary publication · 29090626 (PubMed) · PMC6498753 (PubMed Central)
  6. The impact of common dopamine D2 receptor gene polymorphisms on D2/3 receptor availability: C957T as a key determinant in putamen and ventral striatum. Smith CT, Dang LC, Buckholtz JW, Tetreault AM, Cowan RL, Kessler RM, Zald DH (2017) Transl Psychiatry 7(4): e1091
    › Primary publication · 28398340 (PubMed) · PMC5416688 (PubMed Central)
  7. Neural Systems Underlying Individual Differences in Intertemporal Decision-making. Elton A, Smith CT, Parrish MH, Boettiger CA (2017) J Cogn Neurosci 29(3): 467-479
    › Primary publication · 27779911 (PubMed) · PMC5285502 (PubMed Central)
  8. Variability in paralimbic dopamine signaling correlates with subjective responses to d-amphetamine. Smith CT, Dang LC, Cowan RL, Kessler RM, Zald DH (2016) Neuropharmacology : 394-402
    › Primary publication · 27174408 (PubMed) · PMC4912942 (PubMed Central)
  9. Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology. Smith CT, Weafer J, Cowan RL, Kessler RM, Palmer AA, de Wit H, Zald DH (2016) J Psychopharmacol 30(4): 330-43
    › Primary publication · 26880226 (PubMed) · PMC5049703 (PubMed Central)
  10. Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults. Smith CT, Wallace DL, Dang LC, Aarts E, Jagust WJ, D'Esposito M, Boettiger CA (2016) J Neurophysiol 115(3): 1146-56
    › Primary publication · 26683066 (PubMed) · PMC4808128 (PubMed Central)
  11. Intertemporal Choice Behavior in Emerging Adults and Adults: Effects of Age Interact with Alcohol Use and Family History Status. Smith CT, Steel EA, Parrish MH, Kelm MK, Boettiger CA (2015) Front Hum Neurosci : 627
    › Primary publication · 26635580 (PubMed) · PMC4655234 (PubMed Central)
  12. Ovarian cycle effects on immediate reward selection bias in humans: a role for estradiol. Smith CT, Sierra Y, Oppler SH, Boettiger CA (2014) J Neurosci 34(16): 5468-76
    › Primary publication · 24741037 (PubMed) · PMC3988406 (PubMed Central)
  13. Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator. Swift-Scanlan T, Smith CT, Bardowell SA, Boettiger CA (2014) BMC Med Genomics : 5
    › Primary publication · 24460628 (PubMed) · PMC3910242 (PubMed Central)
  14. Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load. Smith CT, Swift-Scanlan T, Boettiger CA (2014) J Cogn Neurosci 26(2): 395-407
    › Primary publication · 24144248 (PubMed) · PMC3877727 (PubMed Central)
  15. Age modulates the effect of COMT genotype on delay discounting behavior. Smith CT, Boettiger CA (2012) Psychopharmacology (Berl) 222(4): 609-17
    › Primary publication · 22349272 (PubMed) · PMC3401276 (PubMed Central)