Profile

I obtained my Bachelor of Science in Chemistry, with a minor in Economics at the Ateneo de Manila University in the Philippines in 2012. I was admitted to the straight BS-MS Chemistry program and ultimately obtained my Master of Chemistry (Major: Physical Chemistry) in 2014. I did my undergraduate and graduate research in the research groups of Dr. Armando Guidote (Ateneo) and Dr. Gil Claudio (University of the Philippines). We worked on understanding the interactions between carrageenan monomers and polymers using Molecular Dynamics simulations.

I entered Vanderbilt as a Chemistry PhD student (transferred to Quantitative and Chemical Biology) and joined the Chemical and Physical Biology program after joining the laboratory of Dr. Hassane S. Mchaourab at the Department of Molecular Physiology and Biophysics. My research involves the use of Electron Paramagnetic Resonance Spectroscopy (EPR), particularly Double Electron Electron Resonance (DEER) to study the conformational cycle of an ABC transporter that processes and transports a polypeptide. I also continue to do MD simulations to study protein conformational changes.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter. Mishra S, Verhalen B, Stein RA, Wen PC, Tajkhorshid E, Mchaourab HS (2014) Elife : e02740
    › Primary publication · 24837547 (PubMed) · PMC4046567 (PubMed Central)

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    Contact Information

    2215 Garland Avenue
    741 Light Hall
    Nashville, TN 37232
    USA
    (615) 322-3319 (p)
    Email

    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    ABC Transporters Adenosine Triphosphate ATP-Binding Cassette Transporters Biophysics Carrier Proteins Catalytic Domain Cell Membrane Cloning, Molecular DEER EPR Gene Expression Regulation Hydrolysis Membrane proteins Molecular Dynamics Simulation Nanotechnology Nucleotides Protein Conformation Protein Multimerization Spectroscopy Structural Biology