Oakleigh Folkes, B.A.

Official Affiliation: Pharmacology

Profile

Phelan-McDermid Syndrome (P-MS) is a neurodevelopmental disorder caused by a disruption in the SHANK3 gene. Over 80% of patients are diagnosed with Autism Spectrum Disorder (ASD) and display a core symptom of ASD, restricted and repetitive behaviors (RRBs)

The SHANK3B-/- mouse model recapitulates the RRBs found in patients with P-MS, and also exhibits decreases in excitatory synaptic transmission in the striatum.  It is hypothesized that this causes alterations of signaling in the basal ganglia-thalamo-cortical circuitry that regulates movement and is the source of the RRBs. The aim of my work is to determine if we can normalize alterations in basal ganglia-thalamo-cortical signaling and RRBs in SHANK3B-/- mice using pharmacological approaches. 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndrome. Korade Z, Xu L, Harrison FE, Ahsen R, Hart SE, Folkes OM, Mirnics K, Porter NA (2014) Biol Psychiatry 75(3): 215-22
    › Primary publication · 23896203 (PubMed) · PMC3874268 (PubMed Central)
  2. Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith-Lemli-Opitz syndrome. Korade Z, Folkes OM, Harrison FE (2013) Pharmacol Biochem Behav : 101-8
    › Primary publication · 23541496 (PubMed)

Featured Affiliation

No featured affiliations

    View all affiliations

    Contact Information

    No address provided
    3046161751 (p)
    Email

    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    alpha-Tocopherol Animals Animals, Newborn Antioxidants Ascorbic Acid autism spectrum disorder Behavior, Animal Behavior tests Brain Cell Line, Transformed Disease Models, Animal electrophysiolgy Female Fibroblasts Gene Expression Regulation Humans Liver Male Mice Mice, Transgenic Oxidoreductases Acting on CH-CH Group Donors Pharmacology Serotonin Smith-Lemli-Opitz Syndrome Ubiquinone