Nicole Perry
Last active: 2/29/2016

Nicole A Perry, B.S./B.A.

Official Affiliation: Pharmacology

Profile

Following graduation from Wittenberg University, I began my graduate studies at Vanderbilt University.  I chose to pursue my thesis work in the Pharmacology Department under the co-mentorship of Dr. Vsevolod V. Gurevich and Dr. Tina M. Iverson, whose labs I officially joined in April 2015. My chosen thesis research, which is to elucidate how arrestin interacts with effectors, is based on evidence from both of my labs and current publications in the field. As a member of two labs, I am presented with the unique opportunity to approach my scientific questions from two angles: biochemical assays, which allow me to conduct studies of arrestin function, and X-ray crystallography, which I use to determine different arrestin complex structures. This arrangement enables me to develop novel functional experiments with the help of solved crystal structures, a process that usually requires extensive collaboration. It also exposes me to a wide variety of experimental techniques, which range from basic molecular and cell biology to advanced instrumental study. I believe that this gives me an advantage over other students because I have a greater understanding of the assays available to investigate scientific questions.

 

Publications

Xu T, Perry N, Chauhan A, Sayler G, Ripp S. 2014. Microbial indicators for monitoring pollution and bioremediation p.115-132. In Das S (ed.), Microbial Biodegradation and Bioremediation. Elsevier, New York, NY.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Peptide mini-scaffold facilitates JNK3 activation in cells. Zhan X, Stoy H, Kaoud TS, Perry NA, Chen Q, Perez A, Els-Heindl S, Slagis JV, Iverson TM, Beck-Sickinger AG, Gurevich EV, Dalby KN, Gurevich VV (2016) Sci Rep : 21025
    › Primary publication · 26868142 (PubMed) · PMC4751492 (PubMed Central)
  2. Arrestins: Critical Players in Trafficking of Many GPCRs. Gurevich VV, Gurevich EV (2015) Prog Mol Biol Transl Sci : 1-14
    › Primary publication · 26055052 (PubMed) · PMC5841159 (PubMed Central)

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    Contact Information

    2200 Pierce Avenue
    460 Robinson Research Building
    Nashville, TN 37232-6600
    United States
    5132577780 (p)
    Email

    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    Adenosine Triphosphatases Animals Arrestin Arrestins beta-Arrestin 1 beta-Arrestin 2 Binding Sites Cercopithecus aethiops Clathrin COS Cells Endocytosis Enzyme Activation Enzyme Activators Fatty Acid-Binding Proteins Humans Mitogen-Activated Protein Kinase 10 Models, Biological Peptides Pharmacology Phosphorylation Protein Binding Protein Transport Receptors, G-Protein-Coupled Signal Transduction Ubiquitin X-ray crystallography