Joel Harp
Last active: 7/24/2015


Director of Operations for the Biomolecular Crystallography Facility in the Center for Structural Biology


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). Gentry PR, Kokubo M, Bridges TM, Kett NR, Harp JM, Cho HP, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Wood MR, Lindsley CW (2013) J Med Chem 56(22): 9351-5
    › Primary publication · 24164599 (PubMed) · PMC3876027 (PubMed Central)
  2. Total synthesis of stemaphylline N-oxide and related C9a-epimeric analogues. Schulte ML, Turlington ML, Phatak SS, Harp JM, Stauffer SR, Lindsley CW (2013) Chemistry 19(36): 11847-52
    › Primary publication · 23956045 (PubMed) · PMC3925759 (PubMed Central)
  3. Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. Tang D, McKinley ET, Hight MR, Uddin MI, Harp JM, Fu A, Nickels ML, Buck JR, Manning HC (2013) J Med Chem 56(8): 3429-33
    › Primary publication · 23521048 (PubMed) · PMC3648642 (PubMed Central)
  4. Computational design of an endo-1,4-beta-xylanase ligand binding site. Morin A, Kaufmann KW, Fortenberry C, Harp JM, Mizoue LS, Meiler J (2011) Protein Eng Des Sel 24(6): 503-16
    › Primary publication · 21349882 (PubMed) · PMC3092692 (PubMed Central)
  5. Structure and function of YghU, a nu-class glutathione transferase related to YfcG from Escherichia coli. Stourman NV, Branch MC, Schaab MR, Harp JM, Ladner JE, Armstrong RN (2011) Biochemistry 50(7): 1274-81
    › Primary publication · 21222452 (PubMed) · PMC3040281 (PubMed Central)
  6. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ (2010) J Biol Chem 285(45): 34950-9
    › Primary publication · 20810665 (PubMed) · PMC2966109 (PubMed Central)
  7. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR (2010) J Biol Chem 285(3): 1773-80
    › Primary publication · 19923211 (PubMed) · PMC2804335 (PubMed Central)
  8. Analysis of the structure and function of YfcG from Escherichia coli reveals an efficient and unique disulfide bond reductase. Wadington MC, Ladner JE, Stourman NV, Harp JM, Armstrong RN (2009) Biochemistry 48(28): 6559-61
    › Primary publication · 19537707 (PubMed) · PMC2996727 (PubMed Central)
  9. Expedient placement of two fluorescent dyes for investigating dynamic DNA protein interactions in real time. Leuba SH, Anand SP, Harp JM, Khan SA (2008) Chromosome Res 16(3): 451-67
    › Primary publication · 18461484 (PubMed) · PMC2413326 (PubMed Central)
  10. Bullets and silk in the old west. Harp JM (1996) Science 271(5249): 580c-1c
    › Primary publication · 17814904 (PubMed)
  11. X-ray diffraction analysis of crystals containing twofold symmetric nucleosome core particles. Harp JM, Uberbacher EC, Roberson AE, Palmer EL, Gewiess A, Bunick GJ (1996) Acta Crystallogr D Biol Crystallogr 52(Pt 2): 283-8
    › Primary publication · 15299701 (PubMed)
  12. Preparation and crystallization of nucleosome core particle. Hanson BL, Alexander C, Harp JM, Bunick GJ (2004) Methods Enzymol : 44-62
    › Primary publication · 14870658 (PubMed)
  13. A preliminary time-of-flight neutron diffraction study of Streptomyces rubiginosus D-xylose isomerase. Hanson BL, Langan P, Katz AK, Li X, Harp JM, Glusker JP, Schoenborn BP, Bunick GJ (2004) Acta Crystallogr D Biol Crystallogr 60(Pt 2): 241-9
    › Primary publication · 14747699 (PubMed)
  14. The well-tempered protein crystal: annealing macromolecular crystals. Hanson BL, Harp JM, Bunick GJ (2003) Methods Enzymol : 217-35
    › Primary publication · 14674276 (PubMed)
  15. Structure of the heterodimeric ecdysone receptor DNA-binding complex. Devarakonda S, Harp JM, Kim Y, Ozyhar A, Rastinejad F (2003) EMBO J 22(21): 5827-40
    › Primary publication · 14592980 (PubMed) · PMC275426 (PubMed Central)
  16. Structural basis for bile acid binding and activation of the nuclear receptor FXR. Mi LZ, Devarakonda S, Harp JM, Han Q, Pellicciari R, Willson TM, Khorasanizadeh S, Rastinejad F (2003) Mol Cell 11(4): 1093-100
    › Primary publication · 12718893 (PubMed)
  17. Mcg in 2030: new techniques for atomic position determination of immune complexes. Hanson BL, Bunick GJ, Harp JM, Edmundson AB (2002) J Mol Recognit 15(5): 297-305
    › Primary publication · 12447907 (PubMed)
  18. Experiments testing the abatement of radiation damage in D-xylose isomerase crystals with cryogenic helium. Hanson BL, Harp JM, Kirschbaum K, Schall CA, DeWitt K, Howard A, Pinkerton AA, Bunick GJ (2002) J Synchrotron Radiat 9(Pt 6): 375-81
    › Primary publication · 12409625 (PubMed)
  19. The active site of the SET domain is constructed on a knot. Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S (2002) Nat Struct Biol 9(11): 833-8
    › Primary publication · 12389038 (PubMed)
  20. Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Schurter BT, Koh SS, Chen D, Bunick GJ, Harp JM, Hanson BL, Henschen-Edman A, Mackay DR, Stallcup MR, Aswad DW (2001) Biochemistry 40(19): 5747-56
    › Primary publication · 11341840 (PubMed)
  21. Asymmetries in the nucleosome core particle at 2.5 A resolution. Harp JM, Hanson BL, Timm DE, Bunick GJ (2000) Acta Crystallogr D Biol Crystallogr 56(Pt 12): 1513-34
    › Primary publication · 11092917 (PubMed)
  22. Crystal structure and mechanism of a carbon-carbon bond hydrolase. Timm DE, Mueller HA, Bhanumoorthy P, Harp JM, Bunick GJ (1999) Structure 7(9): 1023-33
    › Primary publication · 10508789 (PubMed)
  23. Macromolecular crystal annealing: evaluation of techniques and variables. Harp JM, Hanson BL, Timm DE, Bunick GJ (1999) Acta Crystallogr D Biol Crystallogr 55(Pt 7): 1329-34
    › Primary publication · 10393299 (PubMed)
  24. Macromolecular crystal annealing: overcoming increased mosaicity associated with cryocrystallography. Harp JM, Timm DE, Bunick GJ (1998) Acta Crystallogr D Biol Crystallogr 54(Pt 4): 622-8
    › Primary publication · 9761858 (PubMed)
  25. Large-scale production of palindrome DNA fragments. Palmer EL, Gewiess A, Harp JM, York MH, Bunick GJ (1995) Anal Biochem 231(1): 109-14
    › Primary publication · 8678288 (PubMed)
  26. Preparative separation of nucleosome core particles containing defined-sequence DNA in multiple translational phases. Harp JM, Palmer EL, York MH, Gewiess A, Davis M, Bunick GJ (1995) Electrophoresis 16(10): 1861-4
    › Primary publication · 8586054 (PubMed)
  27. Shape analysis of the histone octamer in solution. Uberbacher EC, Harp JM, Wilkinson-Singley E, Bunick GJ (1986) Science 232(4755): 1247-9
    › Primary publication · 3704649 (PubMed)
  28. DNA sequence patterns in precisely positioned nucleosomes. Uberbacher EC, Harp JM, Bunick GJ (1988) J Biomol Struct Dyn 6(1): 105-20
    › Primary publication · 3271513 (PubMed)
  29. Isolation and characterization of chromatin replication bands and macronuclei from Euplotes eurystomus. Allen RL, Olins AL, Harp JM, Olins DE (1985) Eur J Cell Biol 39(1): 217-23
    › Primary publication · 2417842 (PubMed)