Jason Winnick
Last active: 5/29/2016


I am a Research Assistant Professor in the Department of Molecular Physiology and Biophysics. My current research emphasis is on the role of the liver in the regulation of blood glucose homeostasis in both type 1- and type 2-diabetes. I perform in vivo studies in humans and canines to study these topics.



The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis. Winnick JJ, Kraft G, Gregory JM, Edgerton DS, Williams P, Hajizadeh IA, Kamal MZ, Smith M, Farmer B, Scott M, Neal D, Donahue EP, Allen E, Cherrington AD (2016) J Clin Invest 126(6): 2236-48
    › Primary publication · 27140398 (PubMed) · PMC4887181 (PubMed Central)
  2. Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes. Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Allen EJ, Donahue EP, Rivera N, Winnick JJ, Edgerton DS, Nishimura E, Fledelius C, Brand CL, Cherrington AD (2015) Diabetes 64(10): 3439-51
    › Primary publication · 26085570 (PubMed) · PMC4587648 (PubMed Central)
  3. Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog. Edgerton DS, Moore MC, Winnick JJ, Scott M, Farmer B, Naver H, Jeppesen CB, Madsen P, Kjeldsen TB, Nishimura E, Brand CL, Cherrington AD (2014) Diabetes 63(11): 3946-54
    › Primary publication · 24947349 (PubMed) · PMC4392933 (PubMed Central)
  4. Effects of 11β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis. Winnick JJ, Ramnanan CJ, Saraswathi V, Roop J, Scott M, Jacobson P, Jung P, Basu R, Cherrington AD, Edgerton DS (2013) Am J Physiol Endocrinol Metab 304(7): E747-56
    › Primary publication · 23403942 (PubMed) · PMC3625750 (PubMed Central)
  5. Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion. Winnick JJ, An Z, Kraft G, Ramnanan CJ, Irimia JM, Smith M, Lautz M, Roach PJ, Cherrington AD (2013) Diabetes 62(1): 96-101
    › Primary publication · 22923473 (PubMed) · PMC3526057 (PubMed Central)
  6. A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo. An Z, Winnick JJ, Moore MC, Farmer B, Smith M, Irimia JM, Roach PJ, Cherrington AD (2012) Diabetes 61(10): 2433-41
    › Primary publication · 22688328 (PubMed) · PMC3447895 (PubMed Central)
  7. Regulation of hepatic glucose uptake and storage in vivo. Moore MC, Coate KC, Winnick JJ, An Z, Cherrington AD (2012) Adv Nutr 3(3): 286-94
    › Primary publication · 22585902 (PubMed) · PMC3649460 (PubMed Central)
  8. Hepatic glycogen supercompensation activates AMP-activated protein kinase, impairs insulin signaling, and reduces glycogen deposition in the liver. Winnick JJ, An Z, Ramnanan CJ, Smith M, Irimia JM, Neal DW, Moore MC, Roach PJ, Cherrington AD (2011) Diabetes 60(2): 398-407
    › Primary publication · 21270252 (PubMed) · PMC3028338 (PubMed Central)
  9. A soluble guanylate cyclase-dependent mechanism is involved in the regulation of net hepatic glucose uptake by nitric oxide in vivo. An Z, Winnick JJ, Farmer B, Neal D, Lautz M, Irimia JM, Roach PJ, Cherrington AD (2010) Diabetes 59(12): 2999-3007
    › Primary publication · 20823104 (PubMed) · PMC2992759 (PubMed Central)
  10. A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin. Winnick JJ, An Z, Moore MC, Ramnanan CJ, Farmer B, Shiota M, Cherrington AD (2009) Am J Physiol Endocrinol Metab 297(2): E358-66
    › Primary publication · 19470836 (PubMed) · PMC2724107 (PubMed Central)
  11. Portal infusion of escitalopram enhances hepatic glucose disposal in conscious dogs. An Z, Moore MC, Winnick JJ, Farmer B, Neal DW, Lautz M, Smith M, Rodewald T, Cherrington AD (2009) Eur J Pharmacol 607(1-3): 251-7
    › Primary publication · 19326481 (PubMed) · PMC2775505 (PubMed Central)
  12. Resistance training differentially affects weight loss and glucose metabolism of White and African American patients with type 2 diabetes mellitus. Winnick JJ, Gaillard T, Schuster DP (2008) Ethn Dis 18(2): 152-6
    › Primary publication · 18507266 (PubMed)
  13. Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. Winnick JJ, Sherman WM, Habash DL, Stout MB, Failla ML, Belury MA, Schuster DP (2008) J Clin Endocrinol Metab 93(3): 771-8
    › Primary publication · 18073312 (PubMed) · PMC2266960 (PubMed Central)
  14. Carbohydrate feedings during team sport exercise preserve physical and CNS function. Winnick JJ, Davis JM, Welsh RS, Carmichael MD, Murphy EA, Blackmon JA (2005) Med Sci Sports Exerc 37(2): 306-15
    › Primary publication · 15692328 (PubMed)