Sachin Patel
Last active: 4/15/2019

Profile

Psychosocial stress is a key trigger for the development and exacerbation of a variety of psychiatric disorders including depression, addiction, schizophrenia, and post-traumatic stress disorder. By understanding the molecular, structural, and physiological adaptations in endocannabinoid signaling that occur in response to stress, we hope uncover novel bio-markers and pharmacological targets for drug development. In addition, we hope these investigations will provide insight into the pathophysiology of stress-related neuropsychiatric disorders. We use a variety of techniques including electrophysiology, mass spectrometry, protein biochemistry, genetic models, and functional anatomical studies, to understand the role of endocannabinoids in the brain's response to stress.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety. Bedse G, Hartley ND, Neale E, Gaulden AD, Patrick TA, Kingsley PJ, Uddin MJ, Plath N, Marnett LJ, Patel S (2017) Biol Psychiatry 82(7): 488-499
    › Primary publication · 28438413 (PubMed) · PMC5585044 (PubMed Central)
  2. Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S (2017) Nat Commun : 14782
    › Primary publication · 28348378 (PubMed) · PMC5379055 (PubMed Central)
  3. Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release. Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ (2016) Neuron 91(6): 1244-1252
    › Primary publication · 27618677 (PubMed) · PMC5033724 (PubMed Central)
  4. Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. Doenni VM, Gray JM, Song CM, Patel S, Hill MN, Pittman QJ (2016) Brain Behav Immun : 237-247
    › Primary publication · 27453335 (PubMed) · PMC5461973 (PubMed Central)
  5. Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A (2016) Transl Psychiatry : e809
    › Primary publication · 27187231 (PubMed) · PMC5070047 (PubMed Central)
  6. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. Gamble-George JC, Baldi R, Halladay L, Kocharian A, Hartley N, Silva CG, Roberts H, Haymer A, Marnett LJ, Holmes A, Patel S (2016) Elife
    › Primary publication · 27162170 (PubMed) · PMC4862754 (PubMed Central)
  7. Electrophysiological Measurement of Cannabinoid-Mediated Synaptic Modulation in Acute Mouse Brain Slices. Báldi R, Ghosh D, Grueter BA, Patel S (2016) Curr Protoc Neurosci : 6.29.1-6.29.19
    › Primary publication · 27063786 (PubMed) · PMC4866814 (PubMed Central)
  8. 2-arachidonoylglycerol signaling impairs short-term fear extinction. Hartley ND, Gunduz-Cinar O, Halladay L, Bukalo O, Holmes A, Patel S (2016) Transl Psychiatry : e749
    › Primary publication · 26926885 (PubMed) · PMC4872450 (PubMed Central)
  9. Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. Gray JM, Wilson CD, Lee TT, Pittman QJ, Deussing JM, Hillard CJ, McEwen BS, Schulkin J, Karatsoreos IN, Patel S, Hill MN (2016) Psychoneuroendocrinology : 151-8
    › Primary publication · 26821211 (PubMed) · PMC4788523 (PubMed Central)
  10. Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking. Holleran KM, Wilson HH, Fetterly TL, Bluett RJ, Centanni SW, Gilfarb RA, Rocco LE, Patel S, Winder DG (2016) Neuropsychopharmacology 41(8): 2062-71
    › Primary publication · 26751284 (PubMed) · PMC4908652 (PubMed Central)
  11. Acute and chronic ethanol exposure differentially regulate CB1 receptor function at glutamatergic synapses in the rat basolateral amygdala. Robinson SL, Alexander NJ, Bluett RJ, Patel S, McCool BA (2016) Neuropharmacology : 474-84
    › Primary publication · 26707595 (PubMed) · PMC4912876 (PubMed Central)
  12. Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids. Gunduz-Cinar O, Flynn S, Brockway E, Kaugars K, Baldi R, Ramikie TS, Cinar R, Kunos G, Patel S, Holmes A (2016) Neuropsychopharmacology 41(6): 1598-609
    › Primary publication · 26514583 (PubMed) · PMC4832021 (PubMed Central)
  13. Prefrontal inputs to the amygdala instruct fear extinction memory formation. Bukalo O, Pinard CR, Silverstein S, Brehm C, Hartley ND, Whittle N, Colacicco G, Busch E, Patel S, Singewald N, Holmes A (2015) Sci Adv 1(6)
    › Primary publication · 26504902 (PubMed) · PMC4618669 (PubMed Central)
  14. The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. Patel S, Shonesy BC, Bluett RJ, Winder DG, Colbran RJ (2016) Biol Psychiatry 79(10): e78-e79
    › Primary publication · 26212898 (PubMed)
  15. Neurobiological Interactions Between Stress and the Endocannabinoid System. Morena M, Patel S, Bains JS, Hill MN (2016) Neuropsychopharmacology 41(1): 80-102
    › Primary publication · 26068727 (PubMed) · PMC4677118 (PubMed Central)
  16. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. Gray JM, Vecchiarelli HA, Morena M, Lee TT, Hermanson DJ, Kim AB, McLaughlin RJ, Hassan KI, Kühne C, Wotjak CT, Deussing JM, Patel S, Hill MN (2015) J Neurosci 35(9): 3879-92
    › Primary publication · 25740517 (PubMed) · PMC4348185 (PubMed Central)
  17. Neuroscience: a cellular basis for the munchies. Patel S, Cone RD (2015) Nature 519(7541): 38-40
    › Primary publication · 25707800 (PubMed)
  18. Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes. Brown JA, Ramikie TS, Schmidt MJ, Báldi R, Garbett K, Everheart MG, Warren LE, Gellért L, Horváth S, Patel S, Mirnics K (2015) Mol Psychiatry 20(12): 1499-507
    › Primary publication · 25623945 (PubMed) · PMC4516717 (PubMed Central)
  19. The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. Shonesy BC, Winder DG, Patel S, Colbran RJ (2015) Neuropharmacology : 57-62
    › Primary publication · 25484252 (PubMed) · PMC4312705 (PubMed Central)
  20. Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. Shonesy BC, Bluett RJ, Ramikie TS, Báldi R, Hermanson DJ, Kingsley PJ, Marnett LJ, Winder DG, Colbran RJ, Patel S (2014) Cell Rep 9(5): 1644-1653
    › Primary publication · 25466252 (PubMed) · PMC4268380 (PubMed Central)
  21. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. Bluett RJ, Gamble-George JC, Hermanson DJ, Hartley ND, Marnett LJ, Patel S (2014) Transl Psychiatry : e408
    › Primary publication · 25004388 (PubMed) · PMC4119220 (PubMed Central)
  22. The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury. Tchantchou F, Tucker LB, Fu AH, Bluett RJ, McCabe JT, Patel S, Zhang Y (2014) Neuropharmacology : 427-39
    › Primary publication · 24937045 (PubMed) · PMC4437642 (PubMed Central)
  23. Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation. Hermanson DJ, Gamble-George JC, Marnett LJ, Patel S (2014) Trends Pharmacol Sci 35(7): 358-67
    › Primary publication · 24845457 (PubMed) · PMC4074568 (PubMed Central)
  24. Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses. Ramikie TS, Nyilas R, Bluett RJ, Gamble-George JC, Hartley ND, Mackie K, Watanabe M, Katona I, Patel S (2014) Neuron 81(5): 1111-1125
    › Primary publication · 24607231 (PubMed) · PMC3955008 (PubMed Central)
  25. Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation. Hermanson DJ, Hartley ND, Gamble-George J, Brown N, Shonesy BC, Kingsley PJ, Colbran RJ, Reese J, Marnett LJ, Patel S (2013) Nat Neurosci 16(9): 1291-8
    › Primary publication · 23912944 (PubMed) · PMC3788575 (PubMed Central)
  26. CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. Shonesy BC, Wang X, Rose KL, Ramikie TS, Cavener VS, Rentz T, Baucum AJ, Jalan-Sakrikar N, Mackie K, Winder DG, Patel S, Colbran RJ (2013) Nat Neurosci 16(4): 456-63
    › Primary publication · 23502535 (PubMed) · PMC3636998 (PubMed Central)
  27. Dissociable effects of CB1 receptor blockade on anxiety-like and consummatory behaviors in the novelty-induced hypophagia test in mice. Gamble-George JC, Conger JR, Hartley ND, Gupta P, Sumislawski JJ, Patel S (2013) Psychopharmacology (Berl) 228(3): 401-9
    › Primary publication · 23483200 (PubMed) · PMC3707973 (PubMed Central)
  28. High times for low-frequency stimulation as endocannabinoids engage in hippocampal long-term depression. Patel S (2012) Neuropsychopharmacology 37(3): 583-5
    › Primary publication · 22240538 (PubMed) · PMC3260981 (PubMed Central)
  29. Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress. Ramikie TS, Patel S (2012) Neuroscience : 38-52
    › Primary publication · 21884761 (PubMed) · PMC3236282 (PubMed Central)
  30. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. Sumislawski JJ, Ramikie TS, Patel S (2011) Neuropsychopharmacology 36(13): 2750-61
    › Primary publication · 21849983 (PubMed) · PMC3230498 (PubMed Central)
  31. An odyssey of fear: Homer stresses new mechanisms. Patel S, Winder DG (2010) Biol Psychiatry 68(11): 980-1
    › Primary publication · 21075227 (PubMed) · PMC3035943 (PubMed Central)
  32. Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. McElligott ZA, Klug JR, Nobis WP, Patel S, Grueter BA, Kash TL, Winder DG (2010) Proc Natl Acad Sci U S A 107(5): 2271-6
    › Primary publication · 20133871 (PubMed) · PMC2836642 (PubMed Central)
  33. Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. Patel S, Kingsley PJ, Mackie K, Marnett LJ, Winder DG (2009) Neuropsychopharmacology 34(13): 2699-709
    › Primary publication · 19675536 (PubMed) · PMC2881681 (PubMed Central)
  34. Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. Patel S, Hillard CJ (2008) Eur J Neurosci 27(11): 2821-9
    › Primary publication · 18588527 (PubMed) · PMC2593941 (PubMed Central)
  35. DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons. Scruggs JL, Patel S, Bubser M, Deutch AY (2000) J Neurosci 20(23): 8846-52
    › Primary publication · 11102493 (PubMed)