Danyvid Olivares-Villagomez
Last active: 4/11/2016

Profile

Our bodies are constantly exposed to infectious agents wanting to invade and cause harm. One of the areas with high exposure to foreign antigens is the mucosa of the digestive tract. The mucosal immune system protects the intestines from pathogenic invaders and at the same time discriminates those organisms that are important for our overall homeostasis. My research focuses in the role of a molecule conspicuously expressed in the intestinal epithelial cells (IEC), known as thymus leukemia (TL) antigen, and its interaction with CD8alpha homodimers expressed by intestinal intraepithelial lymphocytes (IEL). IEL are a group of lymphocytes that in the mouse are comprised primarily of TCRalpha-beta and TCRgamma-delta cells. The great majority of these cells express CD8alpha-alpha. It is thought that TL on IEC interacts and modulates the response of CD8alpha-alpha+ cells. To understand the role of the CD8alpha-alpha-TL interaction, we developed a mouse line that lacks expression of TL. We showed that IEL from TL-deficient mice proliferate more in vivo and in vitro, are more cytotoxic and produce larger amounts of IFN-gamma. Moreover, when TL-deficient mice were crossed with TCRalpha-deficient animals (a susceptible strain of mice for the development of IBD), we observed that TL-deficiency increases the severity and the onset of IBD. These results indicate that TL functions as a check point for the prevention of IBD. My current research is trying to understand the molecular mechanisms governing the interaction of TL-CD8alpha-alpha, and how lymphocytes respond in the absence of these two molecules.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. iCD8α cells: living at the edge of the intestinal immune system. Olivares-Villagómez D, Van Kaer L (2015) Oncotarget 6(24): 19964-5
    › Primary publication · 26197090 (PubMed) · PMC4652978 (PubMed Central)
  2. CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Van Kaer L, Algood HMS, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D (2014) Immunity 41(3): 451-464
    › Primary publication · 25220211 (PubMed) · PMC4169715 (PubMed Central)
  3. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. Carbo A, Olivares-Villagómez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HM (2014) MBio 5(4): e01243-14
    › Primary publication · 25053783 (PubMed) · PMC4120195 (PubMed Central)
  4. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Ahmad R, Chaturvedi R, Olivares-Villagómez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB (2014) Mucosal Immunol 7(6): 1340-53
    › Primary publication · 24670427 (PubMed) · PMC4221190 (PubMed Central)
  5. In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ. Van Kaer L, Rabacal WA, Scott Algood HM, Parekh VV, Olivares-Villagómez D (2013) PLoS One 8(7): e67821
    › Primary publication · 23844100 (PubMed) · PMC3701067 (PubMed Central)
  6. Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34. Parekh VV, Wu L, Boyd KL, Williams JA, Gaddy JA, Olivares-Villagómez D, Cover TL, Zong WX, Zhang J, Van Kaer L (2013) J Immunol 190(10): 5086-101
    › Primary publication · 23596309 (PubMed) · PMC3646937 (PubMed Central)
  7. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. Parekh VV, Wu L, Olivares-Villagómez D, Wilson KT, Van Kaer L (2013) J Immunol 190(5): 1948-60
    › Primary publication · 23345328 (PubMed) · PMC3577977 (PubMed Central)
  8. Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule. Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H (2011) Nat Immunol 12(11): 1086-95
    › Primary publication · 21964609 (PubMed) · PMC3197978 (PubMed Central)
  9. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. Olivares-Villagómez D, Algood HM, Singh K, Parekh VV, Ryan KE, Piazuelo MB, Wilson KT, Van Kaer L (2011) J Immunol 187(8): 4051-60
    › Primary publication · 21900182 (PubMed) · PMC3186831 (PubMed Central)
  10. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production. Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB (2011) Gastroenterology 140(1): 265-74
    › Primary publication · 20875416 (PubMed) · PMC3008308 (PubMed Central)
  11. TL and CD8αα: Enigmatic partners in mucosal immunity. Olivares-Villagómez D, Van Kaer L (2010) Immunol Lett 134(1): 1-6
    › Primary publication · 20850477 (PubMed) · PMC2967663 (PubMed Central)
  12. Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L (2008) Proc Natl Acad Sci U S A 105(46): 17931-6
    › Primary publication · 19004778 (PubMed) · PMC2584730 (PubMed Central)
  13. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagómez D, Dragovic S, Hill T, Roopenian DC, Joyce S, Van Kaer L (2006) J Exp Med 203(3): 647-59
    › Primary publication · 16505142 (PubMed) · PMC2118255 (PubMed Central)
  14. Control of homeostatic proliferation by regulatory T cells. Shen S, Ding Y, Tadokoro CE, Olivares-Villagómez D, Camps-Ramírez M, Curotto de Lafaille MA, Lafaille JJ (2005) J Clin Invest 115(12): 3517-26
    › Primary publication · 16294223 (PubMed) · PMC1283941 (PubMed Central)
  15. Glycolipid antigen induces long-term natural killer T cell anergy in mice. Parekh VV, Wilson MT, Olivares-Villagómez D, Singh AK, Wu L, Wang CR, Joyce S, Van Kaer L (2005) J Clin Invest 115(9): 2572-83
    › Primary publication · 16138194 (PubMed) · PMC1193878 (PubMed Central)
  16. Do regulatory T cells play a role in the control of homeostatic proliferation? Curotto de Lafaille MA, Shen S, Olivares-Villagómez D, Camps-Ramírez M, Lafaille JJ (2005) Int Rev Immunol 24(3-4): 269-84
    › Primary publication · 16036378 (PubMed)
  17. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. Parekh VV, Singh AK, Wilson MT, Olivares-Villagómez D, Bezbradica JS, Inazawa H, Ehara H, Sakai T, Serizawa I, Wu L, Wang CR, Joyce S, Van Kaer L (2004) J Immunol 173(6): 3693-706
    › Primary publication · 15356115 (PubMed)
  18. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM, Olivares-Villagómez D, Van Kaer L, Wang X, Xu M (2003) Proc Natl Acad Sci U S A 100(26): 15782-7
    › Primary publication · 14663139 (PubMed) · PMC307645 (PubMed Central)
  19. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Wilson MT, Johansson C, Olivares-Villagómez D, Singh AK, Stanic AK, Wang CR, Joyce S, Wick MJ, Van Kaer L (2003) Proc Natl Acad Sci U S A 100(19): 10913-8
    › Primary publication · 12960397 (PubMed) · PMC196902 (PubMed Central)
  20. Detection of Trypanosoma cruzi DNA within murine cardiac tissue sections by in situ polymerase chain reaction. Lane JE, Ribeiro-Rodrigues R, Olivares-Villagómez D, Vnencak-Jones CL, McCurley TL, Carter CE (2003) Mem Inst Oswaldo Cruz 98(3): 373-6
    › Primary publication · 12886417 (PubMed)
  21. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. Singh AK, Wilson MT, Hong S, Olivares-Villagómez D, Du C, Stanic AK, Joyce S, Sriram S, Koezuka Y, Van Kaer L (2001) J Exp Med 194(12): 1801-11
    › Primary publication · 11748281 (PubMed) · PMC2193577 (PubMed Central)
  22. Regulatory T cells in spontaneous autoimmune encephalomyelitis. Furtado GC, Olivares-Villagómez D, Curotto de Lafaille MA, Wensky AK, Latkowski JA, Lafaille JJ (2001) Immunol Rev : 122-34
    › Primary publication · 11722629 (PubMed)
  23. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. Curotto de Lafaille MA, Muriglan S, Sunshine MJ, Lei Y, Kutchukhidze N, Furtado GC, Wensky AK, Olivares-Villagómez D, Lafaille JJ (2001) J Exp Med 194(9): 1349-59
    › Primary publication · 11696599 (PubMed) · PMC2195981 (PubMed Central)
  24. Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis. Olivares-Villagómez D, Wensky AK, Wang Y, Lafaille JJ (2000) J Immunol 164(10): 5499-507
    › Primary publication · 10799918 (PubMed)
  25. Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. Olivares-Villagómez D, Wang Y, Lafaille JJ (1998) J Exp Med 188(10): 1883-94
    › Primary publication · 9815266 (PubMed) · PMC2212402 (PubMed Central)
  26. Polymerase chain reaction amplification of three different Trypanosoma cruzi DNA sequences from human chagasic cardiac tissue. Olivares-Villagómez D, McCurley TL, Vnencak-Jones CL, Correa-Oliveira R, Colley DG, Carter CE (1998) Am J Trop Med Hyg 59(4): 563-70
    › Primary publication · 9790431 (PubMed)
  27. Detection of Trypanosoma cruzi with the polymerase chain reaction and in situ hybridization in infected murine cardiac tissue. Lane JE, Olivares-Villagomez D, Vnencak-Jones CL, McCurley TL, Carter CE (1997) Am J Trop Med Hyg 56(6): 588-95
    › Primary publication · 9230784 (PubMed)