Karen Joos
Last active: 3/24/2020


The Joos’ research program is divided into two programs. The first seeks to understand the unique laser-tissue properties of new lasers for the development of surgical procedures, and the second seeks to investigate the role of systemic and environmental components upon the regulation of intraocular pressure and blood flow within the eye. The first program is designed to understand the structural and functional significance of new lasers such as the table-top Raman-shifted alexandrite mid-infrared laser with ocular tissues. The broad aims are to investigate the properties of the particular laser energy and identify how these capabilities interact with specific ocular components and biomaterials. A favorable and efficient outcome may proceed to the development of new clinical procedures. Approaches include: histology, morphometry, immunohistochemistry, electroretinography, intraocular pressure response, and biomaterial delivery in models as well as designing unique laser delivery and imaging instruments with endoscopy and optical coherence tomography (OCT). The second program is designed to investigate the role of systemic components such as the autonomic nervous system, and blood pressure upon the regulation of intraocular pressure and blood flow within the eye in healthy aging individuals as well as in diseases such as glaucoma. I hypothesize that ischemia/reperfusion is contributing a larger role to this loss of regulation than is currently believed. Approaches include a rat model, intraocular pressure measurements, histology, morphometry, immunohistochemistry, Western blots, and real-time PCR.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Two Cases of Oculofaciocardiodental (OFCD) Syndrome due to X-Linked BCOR Mutations Presenting with Infantile Hemangiomas: Phenotypic Overlap with PHACE Syndrome. Morgan TM, Colazo JM, Duncan L, Hamid R, Joos KM (2019) Case Rep Genet : 9382640
    › Primary publication · 31956451 (PubMed) · PMC6949664 (PubMed Central)
  2. Three-Year Findings on Intraocular Pressure Changes in The Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) Study. Patel SN, Kim SJ, Lalezary M, Shah R, Kuchtey RW, Joos KM, Kammer JA, Cherney EF (2019) Ophthalmic Surg Lasers Imaging Retina 50(6): 371-376
    › Primary publication · 31233154 (PubMed)
  3. Short-term Optic Disc Cupping Reversal in a Patient With Mild Juvenile Open-angle Glaucoma Due to Early Idiopathic Intracranial Hypertension. Umfress AC, Mawn LA, Joos KM (2019) J Glaucoma 28(4): e53-e57
    › Primary publication · 30531192 (PubMed)
  4. Morphological and functional changes in the rat retina associated with 2 months of intermittent moderate intraocular pressure elevation. Tan B, Gurdita A, Choh V, Joos KM, Prasad R, Bizheva K (2018) Sci Rep 8(1): 7727
    › Primary publication · 29769654 (PubMed) · PMC5955988 (PubMed Central)
  5. Isoflurane and ketamine:xylazine differentially affect intraocular pressure-associated scotopic threshold responses in Sprague-Dawley rats. Choh V, Gurdita A, Tan B, Feng Y, Bizheva K, McCulloch DL, Joos KM (2017) Doc Ophthalmol 135(2): 121-132
    › Primary publication · 28638951 (PubMed) · PMC5693678 (PubMed Central)
  6. Pigmented and albino rats differ in their responses to moderate, acute and reversible intraocular pressure elevation. Gurdita A, Tan B, Joos KM, Bizheva K, Choh V (2017) Doc Ophthalmol 134(3): 205-219
    › Primary publication · 28389912 (PubMed) · PMC5545899 (PubMed Central)
  7. Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography. Malone JD, El-Haddad MT, Bozic I, Tye LA, Majeau L, Godbout N, Rollins AM, Boudoux C, Joos KM, Patel SN, Tao YK (2017) Biomed Opt Express 8(1): 193-206
    › Primary publication · 28101411 (PubMed) · PMC5231292 (PubMed Central)
  8. Glaucoma Disparities in the Hispanic Population. Nathan N, Joos KM (2016) Semin Ophthalmol 31(4): 394-9
    › Primary publication · 27128326 (PubMed)
  9. Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram Responses. Choh V, Gurdita A, Tan B, Prasad RC, Bizheva K, Joos KM (2016) Invest Ophthalmol Vis Sci 57(4): 2140-51
    › Primary publication · 27100161 (PubMed) · PMC4849866 (PubMed Central)
  10. Optic nerve sheath fenestration using a Raman-shifted alexandrite laser. Kozub J, Shen JH, Joos KM, Prasad R, Hutson MS (2016) Lasers Surg Med 48(3): 270-80
    › Primary publication · 27020001 (PubMed) · PMC5058430 (PubMed Central)
  11. Efficacy and predictability of soft tissue ablation using a prototype Raman-shifted alexandrite laser. Kozub JA, Shen JH, Joos KM, Prasad R, Hutson MS (2015) J Biomed Opt 20(10): 105004
    › Primary publication · 26456553 (PubMed) · PMC4963468 (PubMed Central)
  12. Preliminary Design and Evaluation of a B-Scan OCT-Guided Needle. Joos KM, Shen JH (2014) Photonics 1(3): 260-266
    › Primary publication · 26038771 (PubMed) · PMC4450077 (PubMed Central)
  13. Evaluation of microsurgical tasks with OCT-guided and/or robot-assisted ophthalmic forceps. Yu H, Shen JH, Shah RJ, Simaan N, Joos KM (2015) Biomed Opt Express 6(2): 457-72
    › Primary publication · 25780736 (PubMed) · PMC4354581 (PubMed Central)
  14. Primary cilia signaling mediates intraocular pressure sensation. Luo N, Conwell MD, Chen X, Kettenhofen CI, Westlake CJ, Cantor LB, Wells CD, Weinreb RN, Corson TW, Spandau DF, Joos KM, Iomini C, Obukhov AG, Sun Y (2014) Proc Natl Acad Sci U S A 111(35): 12871-6
    › Primary publication · 25143588 (PubMed) · PMC4156748 (PubMed Central)
  15. Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: twelve-month findings. Lalezary M, Shah RJ, Reddy RK, Kammer JA, Kuchtey RW, Joos KM, Cherney EF, Recchia FM, Kim SJ (2014) Ophthalmology 121(10): 1983-9
    › Primary publication · 24907063 (PubMed)
  16. Acute myopia and angle closure glaucoma from topiramate in a seven-year-old: a case report and review of the literature. Rapoport Y, Benegas N, Kuchtey RW, Joos KM (2014) BMC Pediatr : 96
    › Primary publication · 24712825 (PubMed) · PMC3991910 (PubMed Central)
  17. Miniature forward-imaging B-scan optical coherence tomography probe to guide real-time laser ablation. Li Z, Shen JH, Kozub JA, Prasad R, Lu P, Joos KM (2014) Lasers Surg Med 46(3): 193-202
    › Primary publication · 24648326 (PubMed) · PMC3962956 (PubMed Central)
  18. Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months. Reddy RK, Lalezary M, Kim SJ, Kammer JA, Kuchtey RW, Cherney EF, Recchia FM, Joos KM, Agarwal A, Law JC (2013) Clin Ophthalmol : 1761-9
    › Primary publication · 24039396 (PubMed) · PMC3770890 (PubMed Central)
  19. Miniature real-time intraoperative forward-imaging optical coherence tomography probe. Joos KM, Shen JH (2013) Biomed Opt Express 4(8): 1342-50
    › Primary publication · 24009997 (PubMed) · PMC3756577 (PubMed Central)
  20. Pediatric ptosis as a sign of treatable autonomic dysfunction. Phillips L, Robertson D, Melson MR, Garland EM, Joos KM (2013) Am J Ophthalmol 156(2): 370-374.e2
    › Primary publication · 23622564 (PubMed) · PMC3720787 (PubMed Central)
  21. Raman-shifted alexandrite laser for soft tissue ablation in the 6- to 7-µm wavelength range. Kozub J, Ivanov B, Jayasinghe A, Prasad R, Shen J, Klosner M, Heller D, Mendenhall M, Piston DW, Joos K, Hutson MS (2011) Biomed Opt Express 2(5): 1275-81
    › Primary publication · 21559139 (PubMed) · PMC3087584 (PubMed Central)
  22. Long-term results of combined endoscope-assisted pars plana vitrectomy and glaucoma tube shunt surgery. Tarantola RM, Agarwal A, Lu P, Joos KM (2011) Retina 31(2): 275-83
    › Primary publication · 21102370 (PubMed) · PMC3058695 (PubMed Central)
  23. Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure. Joos KM, Li C, Sappington RM (2010) Invest Ophthalmol Vis Sci 51(12): 6431-40
    › Primary publication · 20688743 (PubMed) · PMC3055763 (PubMed Central)
  24. Hollow-glass waveguide delivery of an infrared free-electron laser for microsurgical applications. Shen JH, Harrington JA, Edwards GS, Joos KM (2001) Appl Opt 40(4): 583-7
    › Primary publication · 18357034 (PubMed)
  25. Endoscopic free electron laser technique development for minimally invasive optic nerve sheath fenestration. Shah RJ, Shen JH, Joos KM (2007) Lasers Surg Med 39(7): 589-96
    › Primary publication · 17868109 (PubMed)
  26. Mid infrared optical parametric oscillator (OPO) as a viable alternative to tissue ablation with the free electron laser (FEL). Mackanos MA, Simanovskii D, Joos KM, Schwettman HA, Jansen ED (2007) Lasers Surg Med 39(3): 230-6
    › Primary publication · 17304561 (PubMed)
  27. Central corneal thickness and corneal diameter in patients with childhood glaucoma. Tai TY, Mills MD, Beck AD, Joos KM, Ying GS, Liu C, Piltz-Seymour JR (2006) J Glaucoma 15(6): 524-8
    › Primary publication · 17106366 (PubMed)
  28. Optic nerve sheath fenestration with endoscopic accessory instruments versus the free electron laser (FEL). Joos KM, Shah RJ, Robinson RD, Shen JH (2006) Lasers Surg Med 38(9): 846-51
    › Primary publication · 16977612 (PubMed)
  29. Discontinuing nasal steroids might lower intraocular pressure in glaucoma. Bui CM, Chen H, Shyr Y, Joos KM (2005) J Allergy Clin Immunol 116(5): 1042-7
    › Primary publication · 16275373 (PubMed)
  30. The effect of free-electron laser pulse structure on mid-infrared soft-tissue ablation: biological effects. Mackanos MA, Kozub JA, Hachey DL, Joos KM, Ellis DL, Jansen ED (2005) Phys Med Biol 50(8): 1885-99
    › Primary publication · 15815102 (PubMed)
  31. Development of an orbital endoscope for use with the free electron laser. Mawn LA, Shen JH, Jordan DR, Joos KM (2004) Ophthalmic Plast Reconstr Surg 20(2): 150-7
    › Primary publication · 15083085 (PubMed)
  32. Effect of posture on blood and intraocular pressures in multiple system atrophy, pure autonomic failure, and baroreflex failure. Singleton CD, Robertson D, Byrne DW, Joos KM (2003) Circulation 108(19): 2349-54
    › Primary publication · 14597588 (PubMed)
  33. Chronic and acute analysis of optic nerve sheath fenestration with the free electron laser in monkeys. Joos KM, Mawn LA, Shen JH, Casagrande VA (2003) Lasers Surg Med 32(1): 32-41
    › Primary publication · 12516068 (PubMed)
  34. Supplemental transscleral diode laser cyclophotocoagulation after aqueous shunt placement in refractory glaucoma. Semchyshyn TM, Tsai JC, Joos KM (2002) Ophthalmology 109(6): 1078-84
    › Primary publication · 12045047 (PubMed)
  35. Posterior repositioning of glaucoma implants for anterior segment complications. Joos KM, Laviña AM, Tawansy KA, Agarwal A (2001) Ophthalmology 108(2): 279-84
    › Primary publication · 11158799 (PubMed)
  36. An ocular endoscope enables a goniotomy despite a cloudy cornea. Joos KM, Shen JH (2001) Arch Ophthalmol 119(1): 134-5
    › Primary publication · 11146740 (PubMed)
  37. Optic nerve sheath fenestration with a novel wavelength produced by the free electron laser (FEL). Joos KM, Shen JH, Shetlar DJ, Casagrande VA (2000) Lasers Surg Med 27(3): 191-205
    › Primary publication · 11013381 (PubMed)
  38. Endoscopic goniotomy with the free electron laser in congenital glaucoma rabbits. Sun W, Shen JH, Shetlar DJ, Joos KM (2000) J Glaucoma 9(4): 325-33
    › Primary publication · 10958607 (PubMed)
  39. Effect of acute intraocular pressure changes on short posterior ciliary artery haemodynamics. Joos KM, Kay MD, Pillunat LE, Harris A, Gendron EK, Feuer WJ, Steinwand BE (1999) Br J Ophthalmol 83(1): 33-8
    › Primary publication · 10209431 (PubMed) · PMC1722788 (PubMed Central)
  40. Intraocular pressure and baroreflex failure. Joos KM, Kakaria SK, Lai KS, Shannon JR, Jordan J (1998) Lancet 351(9117): 1704
    › Primary publication · 9734892 (PubMed)
  41. Half corneal light shield as a delivery system for standardized application of mitomycin C. Khoury JM, Joos KM, Shen JH, Davis D, O'Day DM (1998) J Glaucoma 7(1): 8-11
    › Primary publication · 9493108 (PubMed)
  42. Reproducibility of laser Doppler flowmetry in the human optic nerve head. Joos KM, Pillunat LE, Knighton RW, Anderson DR, Feuer WJ (1997) J Glaucoma 6(4): 212-6
    › Primary publication · 9264299 (PubMed)
  43. Ablation rate of PMMA and human cornea with a frequency-quintupled Nd:YAG laser (213 nm). Shen JH, Joos KM, Manns F, Ren Q, Fankhauser F, Denham D, Söderberg PG, Parej JM (1997) Lasers Surg Med 21(2): 179-85
    › Primary publication · 9261795 (PubMed)
  44. Autoregulation of human optic nerve head circulation in response to increased intraocular pressure. Pillunat LE, Anderson DR, Knighton RW, Joos KM, Feuer WJ (1997) Exp Eye Res 64(5): 737-44
    › Primary publication · 9245904 (PubMed)
  45. Acute IOP elevation with scleral suction: effects on retrobulbar haemodynamics. Harris A, Joos K, Kay M, Evans D, Shetty R, Sponsel WE, Martin B (1996) Br J Ophthalmol 80(12): 1055-9
    › Primary publication · 9059269 (PubMed) · PMC505702 (PubMed Central)
  46. Laser Doppler flowmetry measurement of changes in human optic nerve head blood flow in response to blood gas perturbations. Harris A, Anderson DR, Pillunat L, Joos K, Knighton RW, Kagemann L, Martin BJ (1996) J Glaucoma 5(4): 258-65
    › Primary publication · 8795771 (PubMed)
  47. Experimental endoscopic goniotomy. A potential treatment for primary infantile glaucoma. Joos KM, Alward WL, Folberg R (1993) Ophthalmology 100(7): 1066-70
    › Primary publication · 8321530 (PubMed)
  48. Ocular findings associated with a Cys39Arg mutation in the Norrie disease gene. Joos KM, Kimura AE, Vandenburgh K, Bartley JA, Stone EM (1994) Arch Ophthalmol 112(12): 1574-9
    › Primary publication · 7993212 (PubMed)
  49. Systemic diseases associated with nonarteritic anterior ischemic optic neuropathy. Hayreh SS, Joos KM, Podhajsky PA, Long CR (1994) Am J Ophthalmol 118(6): 766-80
    › Primary publication · 7977604 (PubMed)
  50. One-year follow-up results of combined mitomycin C trabeculectomy and extracapsular cataract extraction. Joos KM, Bueche MJ, Palmberg PF, Feuer WJ, Grajewski AL (1995) Ophthalmology 102(1): 76-83
    › Primary publication · 7831046 (PubMed)
  51. The innervation of flexor carpi radialis. An interfascicular dissection. Blair WF, Joos K (1982) Arch Neurol 39(10): 647-9
    › Primary publication · 7125975 (PubMed)
  52. Interrupted and continuous microarteriorrhaphy techniques: a hemodynamic comparison. Blair WF, Pedersen DR, Joos K, Bondi D (1984) J Orthop Res 2(4): 419-24
    › Primary publication · 6396386 (PubMed)
  53. A histologic comparison of continuous and interrupted microarteriorrhaphy. Joos KM, Blair WF, Maynard JA (1985) Microsurgery 6(3): 141-6
    › Primary publication · 3903426 (PubMed)
  54. Peripheral hemodynamic stability during prolonged anesthesia in the rat. Joos KM, Blair WF, Brown TD, Gabel RH (1986) Microsurgery 7(4): 178-82
    › Primary publication · 3796270 (PubMed)
  55. Microarteriorrhaphy: blood flow after wound healing. Blair WF, Pedersen DR, Joos K, Green ER, Bondi D (1985) Microsurgery 6(2): 116-20
    › Primary publication · 3160910 (PubMed)
  56. Microarterial synthetic graft repair: interstitial cellular components. Joos KM, Sandra A (1990) Microsurgery 11(4): 268-77
    › Primary publication · 2255244 (PubMed)
  57. Flow field mapping in the anesthetized rat. Joos KM, Blair WF, Brown TD, Gable RH (1990) Microsurgery 11(1): 12-8
    › Primary publication · 2139157 (PubMed)
  58. A multilens case. Joos KM, Brown DM, Alward WL (1991) Arch Ophthalmol 109(10): 1343-4
    › Primary publication · 1929910 (PubMed)