Tina Iverson
Last active: 4/1/2019

Profile

In humans, transmembrane signaling coordinates tissue and organ function. Inappropriate signaling is associated with numerous diseases, such as heart disease and cancer. All known transmembrane signaling processes require the formation of transient complexes between a membrane-spanning protein and an intracellular binding partner. These transient complexes are similar in some respects to transition states in chemical reactions, i.e. they are unstable, but essential for signaling to occur. Understanding the molecular details of these complexes is important for a complete view of biological signaling. To reveal how information is transferred across a membrane, we are performing x-ray crystallographic analysis of several model systems.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Using In Vitro Pull-Down and In-Cell Overexpression Assays to Study Protein Interactions with Arrestin. Perry NA, Zhan X, Gurevich EV, Iverson TM, Gurevich VV (2019) Methods Mol Biol : 107-120
    › Primary publication · 30919350 (PubMed)
  2. Maturation of the respiratory complex II flavoprotein. Sharma P, Maklashina E, Cecchini G, Iverson TM (2019) Curr Opin Struct Biol : 38-46
    › Primary publication · 30851631 (PubMed)
  3. An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding. McCulloch KM, Yamakawa I, Shifrin DA, McConnell RE, Foegeding NJ, Singh PK, Mao S, Tyska MJ, Iverson TM (2019) J Biol Chem 294(10): 3454-3463
    › Primary publication · 30610115 (PubMed) · PMC6416438 (PubMed Central)
  4. Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Perry NA, Kaoud TS, Ortega OO, Kaya AI, Marcus DJ, Pleinis JM, Berndt S, Chen Q, Zhan X, Dalby KN, Lopez CF, Iverson TM, Gurevich VV (2019) Proc Natl Acad Sci U S A 116(3): 810-815
    › Primary publication · 30591558 (PubMed) · PMC6338856 (PubMed Central)
  5. The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains. Starbird CA, Perry NA, Chen Q, Berndt S, Yamakawa I, Loukachevitch LV, Limbrick EM, Bachmann BO, Iverson TM, McCulloch KM (2018) Biochemistry 57(50): 6827-6837
    › Primary publication · 30525509 (PubMed)
  6. Structural Basis of Arrestin-Dependent Signal Transduction. Chen Q, Iverson TM, Gurevich VV (2018) Trends Biochem Sci 43(6): 412-423
    › Primary publication · 29636212 (PubMed) · PMC5959776 (PubMed Central)
  7. The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS. Maklashina E, Rajagukguk S, Iverson TM, Cecchini G (2018) J Biol Chem 293(20): 7754-7765
    › Primary publication · 29610278 (PubMed) · PMC5961047 (PubMed Central)
  8. Crystal structure of an assembly intermediate of respiratory Complex II. Sharma P, Maklashina E, Cecchini G, Iverson TM (2018) Nat Commun 9(1): 274
    › Primary publication · 29348404 (PubMed) · PMC5773532 (PubMed Central)
  9. New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement. Starbird CA, Tomasiak TM, Singh PK, Yankovskaya V, Maklashina E, Eisenbach M, Cecchini G, Iverson TM (2018) J Struct Biol 202(1): 100-104
    › Primary publication · 29158068 (PubMed) · PMC5835405 (PubMed Central)
  10. Structural basis of arrestin-3 activation and signaling. Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM (2017) Nat Commun 8(1): 1427
    › Primary publication · 29127291 (PubMed) · PMC5681653 (PubMed Central)
  11. Using two-site binding models to analyze microscale thermophoresis data. Tso SC, Chen Q, Vishnivetskiy SA, Gurevich VV, Iverson TM, Brautigam CA (2018) Anal Biochem : 64-75
    › Primary publication · 29054528 (PubMed) · PMC5906060 (PubMed Central)
  12. Structural and biochemical analyses reveal insights into covalent flavinylation of the Complex II homolog quinol:fumarate reductase. Starbird CA, Maklashina E, Sharma P, Qualls-Histed S, Cecchini G, Iverson TM (2017) J Biol Chem 292(31): 12921-12933
    › Primary publication · 28615448 (PubMed) · PMC5546032 (PubMed Central)
  13. Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors. Prokop S, Perry NA, Vishnivetskiy SA, Toth AD, Inoue A, Milligan G, Iverson TM, Hunyady L, Gurevich VV (2017) Cell Signal : 98-107
    › Primary publication · 28461104 (PubMed) · PMC5797668 (PubMed Central)
  14. Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam PM, Iverson TM (2016) Biochemistry 55(42): 5927-5937
    › Primary publication · 27685666 (PubMed) · PMC5388602 (PubMed Central)
  15. A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor. Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE (2016) J Biol Chem 291(37): 19674-86
    › Primary publication · 27462082 (PubMed) · PMC5016700 (PubMed Central)
  16. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM (2016) Glycobiology 26(11): 1222-1234
    › Primary publication · 27037304 (PubMed) · PMC6086536 (PubMed Central)
  17. Peptide mini-scaffold facilitates JNK3 activation in cells. Zhan X, Stoy H, Kaoud TS, Perry NA, Chen Q, Perez A, Els-Heindl S, Slagis JV, Iverson TM, Beck-Sickinger AG, Gurevich EV, Dalby KN, Gurevich VV (2016) Sci Rep : 21025
    › Primary publication · 26868142 (PubMed) · PMC4751492 (PubMed Central)
  18. Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM (2016) J Biol Chem 291(14): 7230-40
    › Primary publication · 26833566 (PubMed) · PMC4817157 (PubMed Central)
  19. Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II. Maklashina E, Rajagukguk S, Starbird CA, McDonald WH, Koganitsky A, Eisenbach M, Iverson TM, Cecchini G (2016) J Biol Chem 291(6): 2904-16
    › Primary publication · 26644464 (PubMed) · PMC4742753 (PubMed Central)
  20. Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. McCulloch KM, McCranie EK, Smith JA, Sarwar M, Mathieu JL, Gitschlag BL, Du Y, Bachmann BO, Iverson TM (2015) Proc Natl Acad Sci U S A 112(37): 11547-52
    › Primary publication · 26240321 (PubMed) · PMC4577193 (PubMed Central)